Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTGRAF)

• Drug Name: Imidazolidin-2-ylidene-o-tolyl-amine Drug Info
• Synonyms: 36318-56-6; Imidazolidine, 2-(2-methylphenylimino)-; N-(2-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine; CHEMBL50430; 785724-64-3; (4,5-dihydro-1H-imidazol-2-yl)-o-tolyl-amine; Imidazolidine,2-(2-methylphenylimino)-; AC1L3KDH; Benzenamine,N-2-imidazolidinylidene-2-methyl-; SCHEMBL8020019; CTK5E5913; CTK1C4679; DTXSID30189852; WLQWOUULTDRZTQ-UHFFFAOYSA-N; ZINC13835980; BDBM50213213; 2-(2-Methylphenylimino)imidazolidine; 2-(2-methylphenylimino)-imidazolidine; AKOS027415754; KB-298713

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 142067
  CAS Number: CAS 36318-56-6
  TTD Drug ID: DMTGRAF

Molecule-Related Drug Atlas

Drug(s) Targeting Adrenergic receptor alpha-1B (ADRA1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methamphetamine	DMPM4SK	Anxiety		Approved	[2]
Propericiazine	DME9JNL	Psychiatric disorder	6E8Z	Approved	[3]
Methoxamine	DMF5XQH	Hypertension	BA00-BA04	Approved	[4]
Phendimetrazine	DM6TS1N	Obesity	5B81	Approved	[5]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[6]
TIOSPIRONE	DME5QDP	N. A.	N. A.	Discontinued in Phase 3	[7]
Sunepitron	DM6M8ZX	N. A.	N. A.	Discontinued in Phase 3	[8]
MAZAPERTINE	DMRHYAU	N. A.	N. A.	Discontinued in Phase 2	[9]
SOU-001	DMPAEK5	Urinary incontinence	MF50.2	Discontinued in Phase 2	[10]
SNAP-5089	DMROJEN	Heart arrhythmia	BC65	Terminated	[11]

Drug(s) Targeting Adrenergic receptor alpha-1D (ADRA1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxazosin	DM9PLRH	Benign prostatic hyperplasia	GA90	Approved	[12]
Armodafinil	DMGB035	Malignant glioma	2A00.0	Approved	[13]
Alfuzosin	DMZVMKF	Benign prostatic hyperplasia	GA90	Approved	[14]
Moxisylyte	DMFCLYW	Erectile dysfunction	HA01.1	Approved	[15]
Terazosin	DM3JCVS	Benign prostatic hyperplasia	GA90	Approved	[16]
Bunazosin	DM4I8O7	Glaucoma/ocular hypertension	9C61	Approved	[17]
Trimazosin	DM1QLST	Congestive heart failure	BD10	Approved	[18]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[6]
DL-017	DMM8GZT	Hypertension	BA00-BA04	Phase 1	[19]
PMID30124346-Compound-LDT8	DM5MUNG	Benign prostatic hyperplasia	GA90	Patented	[20]

Drug(s) Targeting Adrenergic receptor alpha-1A (ADRA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SILODOSIN	DMJSBT6	Benign prostatic hyperplasia	GA90	Approved	[21]
NAFTOPIDIL	DMQ8R4E	Hypertension	BA00-BA04	Approved	[21]
Tamsulosin	DM5QF9V	Benign prostatic hyperplasia	GA90	Approved	[22]
Xatral	DMLHOA0	Benign prostatic hyperplasia	GA90	Approved	[23]
Dutasteride + tamsulosin	DM6P8HU	Benign prostatic hyperplasia	GA90	Phase 3	[24]
Besipirdine	DMLVNTA	Cognitive impairment	6D71	Phase 3	[25]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[6]
PMID30124346-Compound-LDT8	DM5MUNG	Benign prostatic hyperplasia	GA90	Patented	[20]
PMID30124346-Compound-LDT66	DMJMTNL	Benign prostatic hyperplasia	GA90	Patented	[20]
TIOSPIRONE	DME5QDP	N. A.	N. A.	Discontinued in Phase 3	[7]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-1A (ADRA1A)	TTNGILX	ADA1A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1B (ADRA1B)	TTBRKXS	ADA1B_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1D (ADRA1D)	TT34BHT	ADA1D_HUMAN	Inhibitor	[1]

References

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• [10] Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov. 2004 Aug;3(8):673-83.
• [11] Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716.
• [12] The role of combination medical therapy in benign prostatic hyperplasia. Int J Impot Res. 2008 Dec;20 Suppl 3:S33-43.
• [13] Mechanisms of modafinil: A review of current research. Neuropsychiatr Dis Treat. 2007 June; 3(3): 349-364.
• [14] Alfuzosin: a review of the therapeutic use of the prolonged-release formulation given once daily in the management of benign prostatic hyperplasia. Drugs. 2002;62(4):633-53.
• [15] Pharmacokinetics of moxisylyte in healthy volunteers after intracavernous injection of increasing doses. Eur J Clin Pharmacol. 1996;49(5):411-5.
• [16] Induction of prostate apoptosis by alpha1-adrenoceptor antagonists: mechanistic significance of the quinazoline component. Prostate Cancer Prostatic Dis. 2002;5(2):88-95.
• [17] Bunazosin, a selective alpha1-adrenoceptor antagonist, as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage. Cardiovasc Drug Rev. 2005 Spring;23(1):43-56.
• [18] The hypotensive effect of trimazosin is not caused solely by alpha 1-adrenoceptor blockade. J Cardiovasc Pharmacol. 1984 Jan-Feb;6(1):142-50.
• [19] Antihypertensive action and blockade of alpha1-adrenoceptors by DL-017, a quinazoline derivative. J Cardiovasc Pharmacol. 2001 Dec;38(6):893-9.
• [20] 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689.
• [21] Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64.
• [22] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [23] Pharma & Vaccines. Product Development Pipeline. April 29 2009.
• [24] Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
• [25] Alpha-Adrenergic activity and cardiovascular effects of besipirdine HCl (HP 749) and metabolite P7480 in vitro and in the conscious rat and dog. J Pharmacol Exp Ther. 1997 Apr;281(1):337-46.