Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTLO1E)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Immunoproteasome complex (IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KZR-616	DM6VD4L	Dermatomyositis	4A41.0	Phase 2	[2]
Peptide analog 10	DMYKOAM	N. A.	N. A.	Patented	[1]
Peptide analog 40	DM12VO9	N. A.	N. A.	Patented	[1]
PMID29865878-Compound-41	DMSAO52	N. A.	N. A.	Patented	[1]
PMID29865878-Compound-38	DMCZ3SH	N. A.	N. A.	Patented	[1]
Peptide analog 30	DMYEJV0	N. A.	N. A.	Patented	[1]
Peptide analog 16	DMKJ27D	N. A.	N. A.	Patented	[1]
Peptide analog 26	DM8FGZB	N. A.	N. A.	Patented	[1]
Peptide analog 24	DM904T7	N. A.	N. A.	Patented	[1]
PMID29865878-Compound-54	DMED71P	N. A.	N. A.	Patented	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Immunoproteasome complex (IP)	TTSJMN8	NOUNIPROTAC	Inhibitor	[1]

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References

1	A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540.
2	Zetomipzomib (KZR-616) attenuates lupus in mice via modulation of innate and adaptive immune responses. Front Immunol. 2023 Mar 10;14:1043680.