Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTMG02)

Drug Name
US8569313, Inhibitor 15 Drug Info
Synonyms CHEMBL3655686; SCHEMBL19309680; SCHEMBL12998675; US8569313, Inhibitor 15; BDBM104907
Cross-matching ID
PubChem CID
25181492
TTD Drug ID
DMTMG02

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Suppressor of tumorigenicity 14 protein (ST14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
US8569313, Inhibitor 18 DMXTCGM N. A. N. A. Patented [1]
US8569313, Inhibitor 14 DMZV6YT N. A. N. A. Patented [1]
US8569313, Inhibitor 19 DMLXG43 N. A. N. A. Patented [1]
PMID23849879C3 DMUW3MT Discovery agent N.A. Investigative [2]
PMID25489658C4d DMWZJT0 Discovery agent N.A. Investigative [3]
Benzamidine DM37GWL Discovery agent N.A. Investigative [4]
2-nas-phe(3-am)-4-(2-guanidinoethyl)piperidine DMFXKN1 Discovery agent N.A. Investigative [5]
Inhibitor 1 [Colombo et al., 2012] DMUQHMP Discovery agent N.A. Investigative [6]
3-tapap DMKSUV9 Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Suppressor of tumorigenicity 14 protein (ST14) TTPRO7W ST14_HUMAN Inhibitor [1]

References

1 Meta-substituted phenyl sulfonyl amides of secondary amino acid amides, the production thereof, and use thereof as matriptase inhibitors. US8569313.
2 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4547-51.
3 Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J Med Chem. 2015 Jan 22;58(2):598-612.
4 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5 Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase. J Med Chem. 2006 Jul 13;49(14):4116-26.
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2418).