General Information of Drug (ID: DMTMVEW)

Drug Name
JCAR014 Drug Info
Indication
Disease Entry ICD 11 Status REF
Non-hodgkin lymphoma 2B33.5 Phase 1/2 [1]
B-cell lymphoma 2A86 Phase 1 [2]
B-cell non-hodgkin lymphoma 2B33.5 Phase 1 [3]
Diffuse large B-cell lymphoma 2A81 Phase 1 [2]
Mediastinal large B-cell lymphoma 2A60.32 Phase 1 [2]
Cross-matching ID
TTD Drug ID
DMTMVEW

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tisagenlecleucel DMM9BJD Acute lymphoblastic leukaemia 2A85 Approved [4]
Blinatumomab DMGECIJ Acute lymphoblastic leukaemia 2A85 Approved [5]
Axicabtagene ciloleucel DMYHN59 Diffuse large B-cell lymphoma 2A81 Approved [6]
Lisocabtagene maraleucel DMP45ME Large B-cell lymphoma 2A81 Approved [7]
Inebilizumab DMI0RHA Neuromyelitis optica spectrum disorder 8E4A.0 Approved [8]
Tecartus DMYQCWT Mantle cell lymphoma 2A85.5 Approved [9]
Loncastuximab tesirine DMXSVGI Diffuse large B-cell lymphoma 2A81 Approved [10]
Obexelimab DMVIC4J IgG4 related disease 4A43.0 Phase 3 [11]
MOR-208 DMDQOWT Diffuse large B-cell lymphoma 2A81 Phase 2/3 [12]
CART-19 DMST3FM Acute lymphoblastic leukaemia 2A85 Phase 2/3 [13]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
B-lymphocyte surface antigen B4 (CD19) TTW640A CD19_HUMAN CAR-T-Cell-Therapy [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800041075)
2 ClinicalTrials.gov (NCT02706405) JCAR014 and Durvalumab in Treating Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
5 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services
7 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services.
8 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
9 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services.
10 Final results of a phase 1 study of loncastuximab tesirine in relapsed/refractory B-cell non-Hodgkin lymphoma. Blood. 2021 May 13;137(19):2634-2645.
11 Emerging B-Cell Therapies in Systemic Lupus Erythematosus. Ther Clin Risk Manag. 2021 Jan 14;17:39-54.
12 A phase 1 trial of the Fc-engineered CD19 antibody XmAb5574 (MOR00208) demonstrates safety and preliminary efficacy in relapsed CLL. Blood. 2014 Dec 4;124(24):3553-60.
13 ClinicalTrials.gov (NCT03027739) CART-19 Cells For MRD Positive CD19+ ALL