Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTNVP4)

Drug Name

LY97241 Drug Info

Synonyms

LY 97241; LY-97241

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Voltage-gated potassium channel Kv10.1 (KCNH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
clofilium	DMQ37OP	Discovery agent	N.A.	Investigative	[2]
ICA-105574	DMS9H2P	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated potassium channel Kv10.1 (KCNH1)	TT9XKUC	KCNH1_HUMAN	Blocker (channel blocker)	[2]
Voltage-gated potassium channel Kv10.2 (KCNH5)	TTX8LQ0	KCNH5_HUMAN	Blocker (channel blocker)	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2606).
2	Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241. Br J Pharmacol. 2003 Jan;138(1):161-71.
3	Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents. Mol Pharmacol. 2004 May;65(5):1120-9.
4	ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels. Mol Pharmacol. 2013 Apr;83(4):805-13.