Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTO13J)

• Drug Name: Clonazepam Drug Info
• Synonyms: Antelepsin; Antilepsin; Chlonazepam; Cloazepam; Clonazepamum; Clonex; Clonopin; Iktorivil; Kenoket; Klonopin; Landsen; Lktorivil; Lonazep; Melzap; Paxam; Ravotril; Rivatril; Rivoril; Rivotril; Solfidin; Klonopin Rapidly Disintegrating; DF2374250; RO4023; Ro 4023; Ro 54023; Alti-Clonazepam; Clonazepamum [INN-Latin]; Klonopin (TN); Ravotril (TN); Rivatril (TN); Rivotril (TN); Ro 4-8180; Ro 5-4023; Ro-5-4023; Clonazepam (JP15/USP/INN); Clonazepam [USAN:INN:BAN:JAN]; Ro 5-4023/B-7; 1,3-Dihydro-5-(o-chlorophenyl)-7-nitro-3H-1,4-benzodiazepin-2-one; 1,3-Dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one; 5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one; 5-(2-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one; 5-(2-Chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 5-(2-Chlorophenyl)-7-nitro-3H-1,4-benzodiazepin-2(1H)-one; 5-(2-chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one; 5-(o-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one; 5-(o-Chlorophenyl)-7-nitro-1H-1,4-benzodiazepin-2(3H)-one; 5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Nitro-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2(1H)-one

Indication

Disease Entry	ICD 11	Status	REF
Absence epilepsy		Approved	[1]
Epilepsy	8A60-8A68	Approved	[2]
Panic disorder	6B01	Approved	[1]
Seizure disorder	8A6Z	Phase 2	[2]

• Therapeutic Class: Anticonvulsants
• Cross-matching ID:
  PubChem CID: 2802
  ChEBI ID: CHEBI:3756
  CAS Number: CAS 1622-61-3
  TTD Drug ID: DMTO13J
  INTEDE Drug ID: DR0351
  ACDINA Drug ID: D00140

Molecule-Related Drug Atlas

Drug(s) Targeting Gamma-aminobutyric acid receptor (GAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[7]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[8]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[9]
Piperazine	DMTY9LU	Ascariasis	1F62	Approved	[10]
Alpidem	DMN7Y9K	Anxiety disorder	6B00-6B0Z	Approved	[11]
Moxidectin	DMYGHX5	Onchocerciasis	1F6A	Approved	[12]
DP-VPA	DMGOXPQ	Bipolar disorder	6A60	Approved	[13]
ANDROSTERONE	DMITJAK	N. A.	N. A.	Phase 3	[8]
ZK-93423	DMFWMKZ	Epileptic seizures	8A61-8A6Z	Phase 3	[14]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[9]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[15]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[16]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[19]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[21]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[22]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[16]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[23]

Drug(s) Metabolized By RNA cytidine acetyltransferase (hALP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[24]
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[25]
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[26]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[27]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[28]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[29]
Mesalazine	DMOL5IU	Diverticulitis		Approved	[30]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[31]
Netilmicin	DMRD1QK	Bacterial infection	1A00-1C4Z	Approved	[32]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[33]

Drug(s) Metabolized By Oxygen-insensitive NADPH nitroreductase B (nfsB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitrofurazone	DMSM2KE	Skin burns	ME65.0	Approved	[34]
Nitrazepam	DMEGIQ6	Epilepsy	8A60-8A68	Approved	[34]
Flunitrazepam	DMGR5Z3	Insomnia	7A00-7A0Z	Approved	[35]
CB1954	DMVP4YK	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[34]
Nitrobenzodiazepine	DM254EW	N. A.	N. A.	Investigative	[35]
Misonidazole	DMYB0HK	N. A.	N. A.	Investigative	[36]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gamma-aminobutyric acid receptor (GAR)	TTNJYV2	NOUNIPROTAC	Agonist	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[4]
RNA cytidine acetyltransferase (hALP)	DEZV4AP	NAT10_HUMAN	Substrate	[5]
Oxygen-insensitive NADPH nitroreductase B (nfsB)	DE0QLUZ	NFSB_ECOLI	Substrate	[6]

References

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