Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTPRIW)

Drug Name
5-Bromo-6-p-tolylamino-1H-pyrimidine-2,4-dione Drug Info
Synonyms CHEMBL353575; 5-bromo-6-(p-toluidino)uracil; 100763-66-4; 5-Bromo-6-p-tolylamino-1H-pyrimidine-2,4-dione
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44374273
TTD Drug ID
DMTPRIW

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting DNA topoisomerase (TOP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Karenitecin DMCRGY4 Lung cancer 2C25.0 Phase 3 [2]
Icofungipen DMTXNZK Fungal infection 1F29-1F2F Phase 2 [3]
TOPOSTATIN DMNZQO9 Discovery agent N.A. Investigative [4]
6-(3-Ethyl-phenylamino)-1H-pyrimidine-2,4-dione DMKUHN9 Discovery agent N.A. Investigative [5]
N*4*-Benzyl-6-chloro-pyrimidine-2,4-diamine DMNGSQK Discovery agent N.A. Investigative [1]
6-Benzylamino-1H-pyrimidine-2,4-dione DM8FUZL Discovery agent N.A. Investigative [1]
6-(3-Bromo-phenylamino)-1H-pyrimidine-2,4-dione DMMFWYX Discovery agent N.A. Investigative [5]
6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione DMSH107 Discovery agent N.A. Investigative [5]
6-Benzylamino-5-bromo-1H-pyrimidine-2,4-dione DMGJYWF Discovery agent N.A. Investigative [1]
2-Amino-6-(indan-5-ylamino)-3H-pyrimidin-4-one DMECHD0 Discovery agent N.A. Investigative [1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
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Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA topoisomerase (TOP) TT2GPK3 NOUNIPROTAC Inhibitor [1]

References

1 Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. J Med Chem. 1986 May;29(5):676-81.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Crystallization and preliminary X-ray analysis of anti-cancer agent 3-(9-acridinylamino)-5-(hydroxymethyl)aniline complexed with the DNA hexamer d(CGTACG)2. Biochim Biophys Acta. 2003 Jan 3;1625(1):27-9.
4 Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. J Nat Prod. 2001 Feb;64(2):204-7.
5 Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. J Med Chem. 1980 Jan;23(1):34-8.