Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTRMBL)

Drug Name

NBI-6024 Drug Info

Synonyms

Diabetes therapeutics, Neurocrine/Taisho; APL (diabetes), Neurocrine/Taisho; Applied Peptide Ligand(diabetes), Neurocrine/Taisho; Insulin B9-23 peptide analog, Taisho/Neurocrine

Indication

Disease Entry	ICD 11	Status	REF
Type-1 diabetes	5A10	Discontinued in Phase 2	[1]

Cross-matching ID

PubChem CID: 9812645
TTD Drug ID: DMTRMBL

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Insulin (INS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Inulin	DM1Y2JH	Measure kidney function	MG02	Approved	[3]
Insulin Zinc Susp Recombinant Human	DM6MO9X	Diabetic complication	5A2Y	Approved	[3]
Insulin-glargine	DMR4HIW	Diabetic complication	5A2Y	Approved	[3]
Insulin Susp Isophane Recombinant Human	DMW8KI7	Diabetic complication	5A2Y	Approved	[3]
Insulin determir	DM79NZ5	Diabetic complication	5A2Y	Approved	[4]
Insulin Susp Protamine Zinc Beef/Pork	DM0NATE	Diabetic complication	5A2Y	Approved	[3]
Insulin-aspart	DMX7V28	Diabetic complication	5A2Y	Approved	[3]
Insulin degludec	DMPL395	Type-1/2 diabetes	5A10-5A11	Approved	[5]
Insulin-detemir	DMOA4VW	Type-1/2 diabetes	5A10-5A11	Approved	[3]
LY2963016	DMEZ0H5	Type-1/2 diabetes	5A10-5A11	Phase 3	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Insulin (INS)	TTZOPHG	INS_HUMAN	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011773)
2	No effect of the altered peptide ligand NBI-6024 on beta-cell residual function and insulin needs in new-onset type 1 diabetes.Diabetes Care.2009 Nov;32(11):2036-40.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	2005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006).
5	Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
6	Efficacy and safety of LY2963016 insulin glargine compared with insulin glargine (Lantus ) in patients with type 1 diabetes in a randomized controlled trial: the ELEMENT 1 study. Diabetes Obes Metab.2015 Aug;17(8):726-33.