Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTUV7L)

Drug Name

GED-0301 Drug Info

Synonyms

SMAD-7 inhibitor (oligonucleotide, Crohn's disease), Giuliani

Indication

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Smad7 messenger RNA (Smad7 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 28466	DMH96UP	Discovery agent	N.A.	Investigative	[3]
ISIS 28477	DMMOV9U	Discovery agent	N.A.	Investigative	[3]
ISIS 28465	DMQ5JNT	Discovery agent	N.A.	Investigative	[3]
ISIS 28472	DMA4U2P	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mothers against decapentaplegic homolog 7 (SMAD7)	TTW06P4	SMAD7_HUMAN	Inhibitor	[1]
Smad7 messenger RNA (Smad7 mRNA)	TT0J32Z	SMAD7_HUMAN	Inhibitor	[2]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	A phase 1 open-label trial shows that smad7 antisense oligonucleotide (GED0301) does not increase the risk of small bowel strictures in Crohn's disease. Aliment Pharmacol Ther. 2012 Nov;36(9):850-7.
3	US patent application no. 6,159,697, Antisense modulation of Smad7 expression.