Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTXNZK)

Drug Name

Icofungipen Drug Info

Synonyms

PLD-118; 198022-65-0; UNII-I20202Q8M8; BAY-10-8888; I20202Q8M8; Cyclopentanecarboxylic acid, 2-amino-4-methylene-, (1R,2S)-; Icofungipen [INN]; (1R,2S)-2-Amino-4-methylene-cyclopentanecarboxylic acid; PLD118; PLD 118; 156292-16-9; BAY 10-8888; (1r,2s)-2-amino-4-methylidenecyclopentanecarboxylic acid; AC1Q5QVF; AC1L50CI; 2-amino-4-methylenecyclopentane-1-carboxylic acid; SCHEMBL117349; CHEMBL343803; CTK0H0639; DTXSID90173515; RKOUGZGFAYMUIO-RITPCOANSA-N; (1R,2S)-2-amino-4-methylidenecyclopentane-1-carboxylic acid; Icofungipen [INN]; (1R,2S)-2-Amino-4-methylenecyclopentane-1-carboxylic acid; AHMA

Indication

Disease Entry	ICD 11	Status	REF
Fungal infection	1F29-1F2F	Phase 2	[1]

Therapeutic Class

Antifungal Agents

Cross-matching ID

PubChem CID: 216240
CAS Number: CAS 198022-65-0
TTD Drug ID: DMTXNZK

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting DNA topoisomerase (TOP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Karenitecin	DMCRGY4	Lung cancer	2C25.0	Phase 3	[3]
TOPOSTATIN	DMNZQO9	Discovery agent	N.A.	Investigative	[4]
6-(3-Ethyl-phenylamino)-1H-pyrimidine-2,4-dione	DMKUHN9	Discovery agent	N.A.	Investigative	[5]
N4-Benzyl-6-chloro-pyrimidine-2,4-diamine	DMNGSQK	Discovery agent	N.A.	Investigative	[6]
5-Bromo-6-p-tolylamino-1H-pyrimidine-2,4-dione	DMTPRIW	Discovery agent	N.A.	Investigative	[6]
6-Benzylamino-1H-pyrimidine-2,4-dione	DM8FUZL	Discovery agent	N.A.	Investigative	[6]
6-(3-Bromo-phenylamino)-1H-pyrimidine-2,4-dione	DMMFWYX	Discovery agent	N.A.	Investigative	[5]
6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione	DMSH107	Discovery agent	N.A.	Investigative	[5]
6-Benzylamino-5-bromo-1H-pyrimidine-2,4-dione	DMGJYWF	Discovery agent	N.A.	Investigative	[6]
2-Amino-6-(indan-5-ylamino)-3H-pyrimidin-4-one	DMECHD0	Discovery agent	N.A.	Investigative	[6]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting Fungal Isoleucyl t-RNA synthetase (Fung ILS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CB-102930	DMZ3QHF	Bacterial infection	1A00-1C4Z	Terminated	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA topoisomerase (TOP)	TT2GPK3	NOUNIPROTAC	Inhibitor	[2]
Fungal Isoleucyl t-RNA synthetase (Fung ILS1)	TTBZHDM	SYIC_YEAST	Modulator	[1]

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References

1	Efficacy, plasma pharmacokinetics, and safety of icofungipen, an inhibitor of Candida isoleucyl-tRNA synthetase, in treatment of experimental disseminated candidiasis in persistently neutropenic rabbits. Antimicrob Agents Chemother. 2005 May;49(5):2084-92.
2	Crystallization and preliminary X-ray analysis of anti-cancer agent 3-(9-acridinylamino)-5-(hydroxymethyl)aniline complexed with the DNA hexamer d(CGTACG)2. Biochim Biophys Acta. 2003 Jan 3;1625(1):27-9.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. J Nat Prod. 2001 Feb;64(2):204-7.
5	Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. J Med Chem. 1980 Jan;23(1):34-8.
6	Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. J Med Chem. 1986 May;29(5):676-81.
7	Prospects for Aminoacyl-tRNA Synthetase Inhibitors as New Antimicrobial Agents. Antimicrob Agents Chemother. 2005 December; 49(12): 4821-4833.