Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU4MCK)

Drug Name

5'-Deoxy-5'-phenyladenophostin A Drug Info

Synonyms

CHEMBL1161890; 3'-O-(3-O,4-O-Diphosphono-alpha-D-glucopyranosyl)-5'-phenyl-5'-deoxy-2'-adenylic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Inositol 1,4,5-trisphosphate receptor (ITPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitroprusside	DMLUA2J	Hypertension	BA00-BA04	Approved	[2]
D-myo-inositol 1,4,5-trisphosphate	DMNUKIX	Discovery agent	N.A.	Investigative	[3]
ADENOPHOSTIN A	DMV39AW	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inositol 1,4,5-trisphosphate receptor (ITPR)	TTC9IZL	ITPR1_HUMAN; ITPR2_HUMAN; ITPR3_HUMAN	Inhibitor	[1]

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References

1	Synthesis of adenophostin A analogues conjugating an aromatic group at the 5'-position as potent IP3 receptor ligands. J Med Chem. 2006 Sep 21;49(19):5750-8.
2	Prostacyclin and sodium nitroprusside inhibit the activity of the platelet inositol 1,4,5-trisphosphate receptor and promote its phosphorylation. J Biol Chem. 1996 Mar 8;271(10):5545-51.
3	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.