Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUACZF)

Drug Name
(1-Amino-ethyl)-phosphinic acid Drug Info
Synonyms
1-Aminoethylphosphinic acid; AMINOETHYLPHOSPHINIC ACID; 74333-44-1; 71937-28-5; 1-Aminoethylphosphinate; (1-Aminoethyl)phosphonous acid; Aminoethylphosphinic acid [INCI]; Phosphinic acid, (1-aminoethyl)-; Phosphinic acid, P-(1-aminoethyl)-; AC1O4DZP; Phosphinic acid, (1-aminoethyl)-, (+/-)-; 1-aminoethyl phosphinic acid; SCHEMBL579981; (1-aminoethyl)phosphinic acid; (1-Aminoethyl)-phosphinic acid; CTK5D5277; TVKUNRSARHGLNB-UHFFFAOYSA-N; 1-aminoethyl-hydroxy-oxophosphanium; AKOS006273172; Phosphinic acid, (1-aminoethyl)-, (-)-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
53957231
TTD Drug ID
DMUACZF

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Aminopeptidase N (ANPEP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
IP10 C8 DMANRGW Psoriasis vulgaris EA90 Phase 2 [2]
[(125)I] RB129 DMX0G7E Discovery agent N.A. Investigative [3]
KELATORPHAN DMOX8FD Discovery agent N.A. Investigative [4]
(1-Amino-3-phenyl-propyl)-phosphinic acid DMXD697 Discovery agent N.A. Investigative [1]
N1-(3,3-diphenylpropyl)-N3-hydroxymalonamide DM5F04D Discovery agent N.A. Investigative [5]
N1-(4-chlorobenzyl)-2-benzyl-N3-hydroxymalonamide DMTMDZ4 Discovery agent N.A. Investigative [5]
N1,2-dibenzyl-N3-hydroxy-N1-phenethylmalonamide DM1L89K Discovery agent N.A. Investigative [5]
1-aminohexylphosphonic acid DMFUABI Discovery agent N.A. Investigative [6]
(S)-2-Amino-3-phenyl-propane-1-thiol DMMAUKO Discovery agent N.A. Investigative [1]
(Amino-phenyl-methyl)-phosphinic acid DMS4ZVK Discovery agent N.A. Investigative [1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aminopeptidase N (ANPEP) TTPHMWB AMPN_HUMAN Inhibitor [1]

References

1 Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1511-6.
2 Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions. Clin Chem Lab Med. 2009;47(3):253-61.
3 Ontogenic and adult whole body distribution of aminopeptidase N in rat investigated by in vitro autoradiography. Biochimie. 2004 Feb;86(2):105-13.
4 Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes. J Med Chem. 1988 Sep;31(9):1825-31.
5 Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem. 2007 Mar 22;50(6):1322-34.
6 New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13. Bioorg Med Chem. 2010 Apr 15;18(8):2930-6.