Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMULZ4W)

Drug Name

CHR-2797 Drug Info

Synonyms

Tosedostat; Tosedostat, CHR2797, CHR-2797

Indication

Disease Entry	ICD 11	Status	REF
Acute myeloid leukaemia	2A60	Phase 2	[1]
Myelodysplastic syndrome	2A37	Phase 2	[2]
Inflammation	1A00-CA43.1	Terminated	[3]

Therapeutic Class

Anticancer Agents

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Puromycin-sensitive aminopeptidase (NPEPPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ANTAQ	DMA7LUR	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aminopeptidase (AMP)	TTWLEZV	NOUNIPROTAC	Inhibitor	[2]
Puromycin-sensitive aminopeptidase (NPEPPS)	TT371QC	PSA_HUMAN	Inhibitor	[4]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022187)
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014340)
4	CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. Cancer Res. 2008 Aug 15;68(16):6669-79.
5	Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells. Bioorg Med Chem Lett. 2003 Jan 6;13(1):83-6.