Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUQHMP)

• Drug Name: Inhibitor 1 [Colombo et al., 2012] Drug Info
• Synonyms: CHEMBL2086421; inhibitor 1 [Colombo et al., 2012]; GTPL8624; SCHEMBL14232816; BDBM50420334

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 70689167
  TTD Drug ID: DMUQHMP

Molecule-Related Drug Atlas

Drug(s) Targeting Airway trypsin-like protease (TMPRSS11D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID21741839C5	DM8PA2V	Discovery agent	N.A.	Investigative	[5]

Drug(s) Targeting Suppressor of tumorigenicity 14 protein (ST14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US8569313, Inhibitor 18	DMXTCGM	N. A.	N. A.	Patented	[6]
US8569313, Inhibitor 14	DMZV6YT	N. A.	N. A.	Patented	[6]
US8569313, Inhibitor 19	DMLXG43	N. A.	N. A.	Patented	[6]
US8569313, Inhibitor 15	DMTMG02	N. A.	N. A.	Patented	[6]
PMID23849879C3	DMUW3MT	Discovery agent	N.A.	Investigative	[7]
PMID25489658C4d	DMWZJT0	Discovery agent	N.A.	Investigative	[8]
Benzamidine	DM37GWL	Discovery agent	N.A.	Investigative	[9]
2-nas-phe(3-am)-4-(2-guanidinoethyl)piperidine	DMFXKN1	Discovery agent	N.A.	Investigative	[10]
3-tapap	DMKSUV9	Discovery agent	N.A.	Investigative	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Airway trypsin-like protease (TMPRSS11D)	TTWHYC8	TM11D_HUMAN	Inhibitor	[2]
Suppressor of tumorigenicity 14 protein (ST14)	TTPRO7W	ST14_HUMAN	Inhibitor	[3]
Transmembrane protease serine 6 (TMPRSS6)	TTL9KE7	TMPS6_HUMAN	Inhibitor	[4]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8624).
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2420).
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2418).
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2422).
• [5] Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4860-4.
• [6] Meta-substituted phenyl sulfonyl amides of secondary amino acid amides, the production thereof, and use thereof as matriptase inhibitors. US8569313.
• [7] 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4547-51.
• [8] Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J Med Chem. 2015 Jan 22;58(2):598-612.
• [9] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [10] Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase. J Med Chem. 2006 Jul 13;49(14):4116-26.