Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMV86DY)

Drug Name

[131I]-BC8 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
leukaemia	2A60-2B33	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Leukocyte common antigen (PTPRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Iomab-B	DMZA47Y	Acute myeloid leukaemia	2A60	Phase 3	[2]
131I-labelled aCD45	DM3YEV0	Acute myeloid leukaemia	2A60	Phase 3	[3]
LM-CD45	DMR7LKC	Transplant rejection	NE84	Phase 1	[4]
Anti-CD45 mabs	DMZ2D0G	Lymphoma	2A80-2A86	Phase 1	[5]
Iomab-ACT	DMY0QL7	B-cell acute lymphoblastic leukaemia	2B33.3	Phase 1	[6]
OX-30	DMVPG1N	Pain	MG30-MG3Z	Terminated	[7]
Asp-BrPmp-Leu	DMJEZ62	Discovery agent	N.A.	Investigative	[8]
------------------------------------------------------------------------------------


⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Leukocyte common antigen (PTPRC)	TTUS45N	PTPRC_HUMAN	Not Available	[1]

------------------------------------------------------------------------------------

References

1	Development of a marrow transplant regimen for acute leukemia using targeted hematopoietic irradiation delivered by 131I-labeled anti-CD45 antibody, combined with cyclophosphamide and total body irradiation. Blood. 1995 Feb 15;85(4):1122-31.
2	Clinical pipeline report, company report or official report of Actinium Pharmaceuticals.
3	131I-anti-CD45 antibody plus busulfan and cyclophosphamide before allogeneic hematopoietic cell transplantation for treatment of acute myeloid leukemia in first remission. Blood. 2006 Mar 1;107(5):2184-91.
4	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002932)
5	CD45 monoclonal antibody-mediated cytolysis of human NK and T lymphoma cells. Haematologica. 2006 Jul;91(7):886-94.
6	Clinical pipeline report, company report or official report of Actinium Pharmaceuticals.
7	CD45 / PTPRC Antibody, Biotin conjugate (OX-30).
8	A protected l-bromophosphonomethylphenylalanine amino acid derivative (BrPmp) for synthesis of irreversible protein tyrosine phosphatase inhibitors. Bioorg Med Chem. 2010 Dec 15;18(24):8679-86.