Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVN5OH)

Drug Name

Minocycline Drug Info

Synonyms

Borymycin; MINO; MIY; Minociclina; Minociclinum; Minocin; Minocline; Minocyclin; Minocyclinum; Minocycline Monohydrochloride; CL 59806; Lactoferrin B & Minocycline; Lactoferrin H & Minocycline; Minociclina [INN-Spanish]; Minocin (Hydrochloride); Minocin (TN); Minocyclinum [INN-Latin]; Vectrin (Hydrochloride); CRL-1605 & Minocycline; Minocycline (USAN/INN); Minocycline [USAN:BAN:INN]; (2Z,4S,4aS,5aR,12aS)-2-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE; 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide; 7-Dimethylamino-6-demethyl-6-deoxytetracycline

Indication

Disease Entry	ICD 11	Status	REF
Acne vulgaris	ED80	Approved	[1]
Actinomycosis		Approved	[1]
Acute gonococcal cervicitis		Approved	[1]
Bacterial infection	1A00-1C4Z	Approved	[2]
Bartonellosis		Approved	[1]
Bronchitis	CA20	Approved	[1]
Brucellosis		Approved	[1]
Chancroid		Approved	[1]
Listeriosis		Approved	[1]
Lymphogranuloma venereum		Approved	[1]
Ornithosis		Approved	[1]
Periodontitis	DA0C	Approved	[1]
Pneumonia	CA40	Approved	[1]
Q fever		Approved	[1]
Relapsing fever		Approved	[1]
Rickettsialpox		Approved	[1]
Rocky mountain spotted fever		Approved	[1]
Syphilis		Approved	[1]
Trachoma		Approved	[1]
Tularemia	1B94	Approved	[1]
Typhus		Approved	[1]
Urinary tract infection	GC08	Approved	[1]
Yaws		Approved	[1]
Rosacea	ED90.0	Phase 2	[3]
Plague		Investigative	[1]
Sinusitis	CA0A.Z	Investigative	[1]
Vibrio cholerae infection	1A00	Investigative	[1]

Therapeutic Class

Antibiotics

Cross-matching ID

PubChem CID: 54675783
ChEBI ID: CHEMBL50694
CAS Number: CAS 10118-90-8
TTD Drug ID: DMVN5OH
VARIDT Drug ID: DR00568
ACDINA Drug ID: D00437

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[5]
Framycetin	DMF8DNE	Acute liver failure	DB91	Approved	[6]
Netilmicin	DMRD1QK	Bacterial infection	1A00-1C4Z	Approved	[7]
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[8]
Clomocycline	DM0ZRMQ	Bacterial infection	1A00-1C4Z	Approved	[9]
Spectinomycin	DM0MQ35	Acute gonococcal cervicitis		Approved	[10]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[11]
Lymecycline	DMOMLHJ	Bacterial infection	1A00-1C4Z	Approved	[12]
Rolitetracycline	DMBR5Q7	Acne vulgaris	ED80	Approved	[13]
Meclocycline	DMSFQ8I	Bacterial infection	1A00-1C4Z	Approved	[14]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)	TTQ8KVI	F4NA87_STAAU	Binder	[4]

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References

1	Minocycline FDA Label
2	Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrob Agents Chemother. 2006 Jun;50(6):2156-66.
5	The glycylcyclines: a comparative review with the tetracyclines. Drugs. 2004;64(1):63-88.
6	Characterization of a 30S ribosomal subunit assembly intermediate found in Escherichia coli cells growing with neomycin or paromomycin. Arch Microbiol. 2008 May;189(5):441-9.
7	Ribosomal resistance in the gentamicin producer organism Micromonospora purpurea. Antimicrob Agents Chemother. 1982 Aug;22(2):231-6.
8	Bacterial resistance to aminoglycosides and beta-lactams: the Tn1331 transposon paradigm. Front Biosci. 2000 Jan 1;5:D20-9.
9	Molecular dynamics simulations of the 30S ribosomal subunit reveal a preferred tetracycline binding site. J Am Chem Soc. 2008 Jan 30;130(4):1114-5.
10	Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature. 2000 Sep 21;407(6802):340-8.
11	Aminoglycoside association pathways with the 30S ribosomal subunit. J Phys Chem B. 2009 May 21;113(20):7322-30.
12	Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
13	Reversed-phase high-performance liquid chromatography coupled to ultraviolet and electrospray time-of-flight mass spectrometry on-line detection fo... J Chromatogr A. 2008 Jun 27;1195(1-2):107-16.
14	Detection of tetracycline resistance genes by PCR methods. Methods Mol Biol. 2004;268:3-13.