Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVN5OH)

Drug Name
Minocycline Drug Info
Synonyms
Borymycin; MINO; MIY; Minociclina; Minociclinum; Minocin; Minocline; Minocyclin; Minocyclinum; Minocycline Monohydrochloride; CL 59806; Lactoferrin B & Minocycline; Lactoferrin H & Minocycline; Minociclina [INN-Spanish]; Minocin (Hydrochloride); Minocin (TN); Minocyclinum [INN-Latin]; Vectrin (Hydrochloride); CRL-1605 & Minocycline; Minocycline (USAN/INN); Minocycline [USAN:BAN:INN]; (2Z,4S,4aS,5aR,12aS)-2-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE; 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide; 7-Dimethylamino-6-demethyl-6-deoxytetracycline
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [1]
Actinomycosis Approved [1]
Acute gonococcal cervicitis Approved [1]
Bacterial infection 1A00-1C4Z Approved [2]
Bartonellosis Approved [1]
Bronchitis CA20 Approved [1]
Brucellosis Approved [1]
Chancroid Approved [1]
Listeriosis Approved [1]
Lymphogranuloma venereum Approved [1]
Ornithosis Approved [1]
Periodontitis DA0C Approved [1]
Pneumonia CA40 Approved [1]
Q fever Approved [1]
Relapsing fever Approved [1]
Rickettsialpox Approved [1]
Rocky mountain spotted fever Approved [1]
Syphilis Approved [1]
Trachoma Approved [1]
Tularemia 1B94 Approved [1]
Typhus Approved [1]
Urinary tract infection GC08 Approved [1]
Yaws Approved [1]
Rosacea ED90.0 Phase 2 [3]
Plague Investigative [1]
Sinusitis CA0A.Z Investigative [1]
Vibrio cholerae infection 1A00 Investigative [1]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
54675783
ChEBI ID
CHEBI:50694
CAS Number
CAS 10118-90-8
TTD Drug ID
DMVN5OH
VARIDT Drug ID
DR00568
ACDINA Drug ID
D00437

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tetracycline DMZA017 Acne vulgaris ED80 Approved [6]
Framycetin DMF8DNE Acute liver failure DB91 Approved [7]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [8]
Amikacin DM5PDRB Bacteremia 1A73 Approved [9]
Clomocycline DM0ZRMQ Bacterial infection 1A00-1C4Z Approved [10]
Spectinomycin DM0MQ35 Acute gonococcal cervicitis Approved [11]
Paromomycin DM1AGXN Amoebiasis 1A36 Approved [12]
Lymecycline DMOMLHJ Bacterial infection 1A00-1C4Z Approved [13]
Rolitetracycline DMBR5Q7 Acne vulgaris ED80 Approved [14]
Meclocycline DMSFQ8I Bacterial infection 1A00-1C4Z Approved [15]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fomepizole DM6VOWQ Athylene glycol or methanol poisoning NE61 Approved [16]
Ademetionine DMYQDBO Hepatic fibrosis DB93.0 Approved [17]
Theophylline DMRJFN9 Bronchitis CA20 Approved [5]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [18]
Ethanol DMDRQZU Chronic pain MG30 Approved [19]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [20]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [5]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [23]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) TTQ8KVI F4NA87_STAAU Binder [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cytochrome P450 2E1 (CYP2E1) OTHQ17JG CP2E1_HUMAN Drug Response [5]

References

1 Minocycline FDA Label
2 Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrob Agents Chemother. 2006 Jun;50(6):2156-66.
5 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
6 The glycylcyclines: a comparative review with the tetracyclines. Drugs. 2004;64(1):63-88.
7 Characterization of a 30S ribosomal subunit assembly intermediate found in Escherichia coli cells growing with neomycin or paromomycin. Arch Microbiol. 2008 May;189(5):441-9.
8 Ribosomal resistance in the gentamicin producer organism Micromonospora purpurea. Antimicrob Agents Chemother. 1982 Aug;22(2):231-6.
9 Bacterial resistance to aminoglycosides and beta-lactams: the Tn1331 transposon paradigm. Front Biosci. 2000 Jan 1;5:D20-9.
10 Molecular dynamics simulations of the 30S ribosomal subunit reveal a preferred tetracycline binding site. J Am Chem Soc. 2008 Jan 30;130(4):1114-5.
11 Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature. 2000 Sep 21;407(6802):340-8.
12 Aminoglycoside association pathways with the 30S ribosomal subunit. J Phys Chem B. 2009 May 21;113(20):7322-30.
13 Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
14 Reversed-phase high-performance liquid chromatography coupled to ultraviolet and electrospray time-of-flight mass spectrometry on-line detection fo... J Chromatogr A. 2008 Jun 27;1195(1-2):107-16.
15 Detection of tetracycline resistance genes by PCR methods. Methods Mol Biol. 2004;268:3-13.
16 Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity. Eur J Drug Metab Pharmacokinet. 2011 Mar;36(1):1-16.
17 Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochem Pharmacol. 2005 Apr 1;69(7):1081-93.
18 Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol. 2012 Apr;28(2):69-87.
19 An in vitro model of human acute ethanol exposure that incorporates CXCR3- and CXCR4-dependent recruitment of immune cells. Toxicol Sci. 2013 Mar;132(1):131-41.
20 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
21 Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver. Arch Toxicol. 2022 Oct;96(10):2739-2754. doi: 10.1007/s00204-022-03338-7. Epub 2022 Jul 26.
22 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
23 Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. Chem Biol Interact. 2004 Apr 15;147(3):331-40.