Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVO0LU)

Drug Name

131I-81C6 Drug Info

Synonyms

Neuradiab; MAb-81C6; Iodine-131-81C6; Astatine-211-MAb-81C6; Iodine-131-MAb-81C6; Iodine-131-ch-81C6; Iodine-131-ch-81C6-F(ab)2; 211At-MAb-81C6

Indication

Disease Entry	ICD 11	Status	REF
Brain cancer	2A00	Terminated	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Tenascin (TNC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
F-16-IL-2 fusion protein	DMJ4BKT	Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]
F-16-131I	DM49BX1	Haematological malignancy	2B33.Y	Phase 1/2	[3]
8H9	DMQ789Z	Brain cancer	2A00	Phase 1	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Human IgG2 constant region enhances in vivo stability of anti-tenascin antibody 81C6 compared with its murine parent. Clin Cancer Res. 1998 Oct;4(10):2495-502.
2	National Cancer Institute Drug Dictionary (drug id 674718).
3	Tumor-Associated Fibroblasts and their Matrix. Springer. Margareta M. Mueller,Norbert E. Fusenig, 2011. Page(775).
4	In vitro and in vivo cytotoxic activities of recombinant immunotoxin 8H9(Fv)-PE38 against breast cancer, osteosarcoma, and neuroblastoma. Cancer Res. 2004 Feb 15;64(4):1419-24.