Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVS9WQ)

Drug Name

Nitisinone Drug Info

Synonyms

Nitisinona; Nitisinonum; Nitisone; Orfadin; Nitisinone [INN]; SC 0735; FE-0200; Nitisinone (NTBC); Nitisinone [USAN:INN]; Orfadin (TN); Nitisinone (JAN/USAN/INN); 2-(2-Nitro-4-trifluoromethylbenzoyl)cyclohexane-1,3-dione; 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione; 2-(Alpha,alpha,alpha-trifluoro-2-nitro-p-tuluoyl)-1,3-cyclohexanedione; 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione; 2-{[2-nitro-4-(trifluoromethyl)phenyl]carbonyl}cyclohexane-1,3-dione

Indication

Disease Entry	ICD 11	Status	REF
Hereditary tyrosinemia type 1	5C50.11	Approved	[1]

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID: 115355
ChEBI ID: CHEBI:50378
CAS Number: CAS 104206-65-7
TTD Drug ID: DMVS9WQ
ACDINA Drug ID: D00474

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Hydroxyphenylpyruvate dioxygenase (HPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BMS-433771	DME20VP	Respiratory syncytial virus infection	1C80	Terminated	[3]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[4]
2-(2-Nitro-benzoyl)-cyclohexane-1,3-dione	DMUJQX1	Discovery agent	N.A.	Investigative	[5]
2-(2-Iodo-benzoyl)-cyclohexane-1,3-dione	DMSVHU9	Discovery agent	N.A.	Investigative	[5]
2-(2-Bromo-benzoyl)-cyclohexane-1,3-dione	DM3VH7F	Discovery agent	N.A.	Investigative	[5]
Diketonitrile	DMPKQER	Discovery agent	N.A.	Investigative	[6]
2-(2-Methoxy-benzoyl)-cyclohexane-1,3-dione	DMESMBO	Discovery agent	N.A.	Investigative	[5]
3-Hydroxy-4-phenyl-5H-furan-2-one	DM5QZDL	Discovery agent	N.A.	Investigative	[7]
(4-Hydroxy-phenoxy)-acetic acid	DMRCM5O	Discovery agent	N.A.	Investigative	[7]
2-(2-Chloro-benzoyl)-cyclohexane-1,3-dione	DMG6ABE	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hydroxyphenylpyruvate dioxygenase (HPD)	TT8DSFC	HPPD_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6834).
2	Experience of nitisinone for the pharmacological treatment of hereditary tyrosinaemia type 1. Expert Opin Pharmacother. 2008 May;9(7):1229-36.
3	Emerging drugs for respiratory syncytial virus infection. Expert Opin Emerg Drugs. 2009 Jun;14(2):207-17.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg Med Chem Lett. 2000 May 1;10(9):843-5.
6	4-Hydroxyphenylpyruvate dioxygenase as a drug discovery target. Drug News Perspect. 2003 Oct;16(8):493-6.
7	Design, synthesis, and evaluation of postulated transient intermediate and substrate analogues as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1709-13.