Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVSQFI)

Drug Name

3-Phenethyl-2-phenyl-3H-quinazolin-4-one Drug Info

Synonyms

3-Phenethyl-2-phenyl-3H-quinazolin-4-one; CHEMBL180391; AC1LJAK1; Oprea1_440152; SCHEMBL5777984; MolPort-002-576-141; KANHEDFPOIQKTH-UHFFFAOYSA-N; ZINC546443; BDBM50162540; STL361550; 3-phenethyl-2-phenylquinazolin-4-one; AKOS003179499; MCULE-6975064033; 3-Phenethyl-2-phenylquinazoline-4(3H)-one; 2-phenyl-3-(2-phenylethyl)quinazolin-4(3H)-one

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 947434
TTD Drug ID: DMVSQFI

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Extracellular calcium-sensing receptor (CASR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[2]
Etelcalcetide	DMHP9BL	Secondary hyperparathyroidism	5A51.1	Approved	[3]
Encaleret	DMQSPFS	Autosomal dominant hypocalcemia	5A50.0Y	Phase 3	[4]
ASP7991	DM3TN1A	Hyperparathyroidism	5A51	Phase 2	[5]
MK-5442	DMHTIGU	Osteoporosis	FB83.0	Phase 2	[6]
ATF-936	DMWGKHZ	Osteoporosis	FB83.0	Phase 1	[7]
AXT-914	DM7ZU3B	Osteoporosis	FB83.0	Phase 1	[8]
R-568	DM5NWPD	N. A.	N. A.	Discontinued in Phase 2	[9]
Ronacaleret	DM10ZJP	Osteoporosis	FB83.0	Discontinued in Phase 2	[10]
NPS-2143	DMQPXLF	Osteoporosis	FB83.0	Discontinued in Phase 2	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Extracellular calcium-sensing receptor (CASR)	TTBUYHA	CASR_HUMAN	Inhibitor	[1]

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References

1	3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1557-60.
2	Clinical pipeline report, company report or official report of Amgen (2009).
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
5	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035616)
6	Antagonist for calcium-sensing receptor. JTT-305/MK-5442. Clin Calcium. 2011 Jan;21(1):89-93.
7	ATF936, a novel oral calcilytic, increases bone mineral density in rats and transiently releases parathyroid hormone in humans. Bone. 2011 Aug;49(2):233-41.
8	AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women. Bone. 2014 Jul;64:204-10.
9	Mixed-effects modeling of the pharmacodynamic response to the calcimimetic agent R-568. Clin Pharmacol Ther. 1999 Jan;65(1):40-9.
10	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
11	Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Abeta42 prompted by exogenous fibrillary or soluble Abeta25-35 in human cortical astrocytes and neurons-therapeutic relevance to Alzheimer's disease. Biochim Biophys Acta. 2013 Oct;1832(10):1634-52.