Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMW4850)

Drug Name

RY796 Drug Info

Synonyms

RY 796; RY-796

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Voltage-gated potassium channel Kv2.1 (KCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[3]
DABCO-C16	DMN3GTF	Discovery agent	N.A.	Investigative	[4]
3-bicyclo[2.2.1]hept-2-yl-benzene-1,2-diol	DMZ8WMA	Discovery agent	N.A.	Investigative	[5]
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Drug(s) Targeting Voltage-gated potassium channel Kv2.2 (KCNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated potassium channel Kv2.1 (KCNB1)	TT5OEKU	KCNB1_HUMAN	Inhibitor (gating inhibitor)	[2]
Voltage-gated potassium channel Kv2.2 (KCNB2)	TT5PFNG	KCNB2_HUMAN	Inhibitor (gating inhibitor)	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7759).
2	Identification of novel and selective Kv2 channel inhibitors. Mol Pharmacol. 2011 Dec;80(6):959-64.
3	Modulation of Kv2.1 channel gating and TEA sensitivity by distinct domains of SNAP-25. Biochem J. 2006 Jun 1;396(2):363-9.
4	1,4-Diazabicyclo[2.2.2]octane derivatives: a novel class of voltage-gated potassium channel blockers. Mol Pharmacol. 2006 Mar;69(3):718-26.
5	Novel neuroprotective K+ channel inhibitor identified by high-throughput screening in yeast. Mol Pharmacol. 2004 Jan;65(1):214-9.
6	Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles. Am J Physiol. 1998 May;274(5 Pt 1):G901-11.