Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMW9GT7)

Drug Name

DwLIP-GCGRrx Drug Info

Synonyms

UNII-T450D0Q71D; 1-Nitro-9-(3-dimethylaminopropylamino)-acridine dihydrochloride; 6514-85-8; Nitracrine HCl; ACRIDINE, 9-((3-(DIMETHYLAMINO)PROPYL)AMINO)-1-NITRO-, DIHYDROCHLORIDE; T450D0Q71D; 1,3-Propanediamine, N,N-dimethyl-N'-(1-nitro-9-acridinyl)-, dihydrochloride; CCRIS 9297; AC1L2LHF; SCHEMBL1652148; LS-14357; 1-NITRO-9-(DIMETHYLAMINOPROPYLAMINO)ACRIDINE DIHYDROCHLORIDE; dimethyl-[3-[(1-nitroacridin-9-yl)azaniumyl]propyl]azanium dichloride

Indication

Disease Entry	ICD 11	Status	REF
Diabetic complication	5A2Y	Investigative	[1]

Cross-matching ID

PubChem CID: 23015
CAS Number: CAS 6514-85-8
TTD Drug ID: DMW9GT7

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Glucagon receptor (GCGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glucagon recombinant	DMFLUTR	Hypoglycemia	5A41	Approved	[2]
Dasiglucagon	DM74SVE	Hypoglycemia	5A41	Approved	[3]
Retatrutide	DM8WU0Q	Obesity	5B81	Phase 3	[4]
MK-8521	DMVNAYE	Type-2 diabetes	5A11	Phase 2	[5]
LY2944876	DML6XWR	Diabetic complication	5A2Y	Phase 2	[6]
TT-401	DMRQ0SA	Type-2 diabetes	5A11	Phase 2	[5]
LGD-6972	DMPL9KG	Type-2 diabetes	5A11	Phase 2	[7]
PF-06291874	DMN94QM	Type-2 diabetes	5A11	Phase 2	[8]
LY-2409021	DMZOIP4	Type-2 diabetes	5A11	Phase 2	[9]
REMD 477	DM13OVF	Type-1 diabetes	5A10	Phase 2	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucagon receptor (GCGR)	TT9O6WS	GLR_HUMAN	Binder	[1]

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References

1	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
2	Glucagon receptor expression and glucagon stimulation of ghrelin secretion in rat stomach. Biochem Biophys Res Commun. 2007 Jun 15;357(4):865-70.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021
4	Is retatrutide (LY3437943), a GLP-1, GIP, and glucagon receptor agonist a step forward in the treatment of diabetes and obesity? Expert Opin Investig Drugs. 2023 May;32(5):355-359.
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
7	Addressing Unmet Medical Needs in Type 2 Diabetes: A Narrative Review of Drugs under Development. Curr Diabetes Rev. 2015 March; 11(1): 17-31.
8	Clinical pipeline report, company report or official report of pfizer.
9	Short-term administration of the glucagon receptor antagonist LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes. Diabetes Obes Metab. 2015 Apr;17(4):414-22.
10	Effect of a glucagon receptor antibody (REMD-477) in type 1 diabetes: A randomized controlled trial. Diabetes Obes Metab. 2018 May;20(5):1302-1305.