Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWB43U)

Drug Name
6-Chloropurine Riboside, 5'-Monophosphate Drug Info
Synonyms
6-Cl-Purine Ribotide; CHEMBL1683023; 6-Chloropurine riboside 5'-phosphate; 6-Chloropurine riboside 5'-monophosphate; 6-Chloropurine ribotide; AC1L4ML7; AC1Q3SV8; 6-Chloroinosine monophosphate; SCHEMBL622623; 6-chloro-9-(5-o-phosphono-; A-d-ribofuranosyl)-9h-purine; ALOBOMYIOYNCBS-KQYNXXCUSA-N; ZINC13526959; BDBM50222697; A8843; 6-Chloropurine 9-beta-D-ribofuranosyl 5'-monophosphate; 6-Chloro-9-(5-O-phosphono-beta-D-ribofuranosyl)-9H-purine; [(2R,3S,4R,5R)-5-(6-chloropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen pho
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
17753915
TTD Drug ID
DMWB43U

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [2]
Urea and carbamate bioisostere derivative 1 DMEQFXZ N. A. N. A. Patented [3]
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [1]
Inosinic Acid DMLR86H Discovery agent N.A. Investigative [1]
Mycophenolic hydroxamic acid DM4YRAH Discovery agent N.A. Investigative [4]
Tiazofurin adenine dinucleotide DMEFVPH Discovery agent N.A. Investigative [5]
Mycophenolic bis(sulfonamide) DMUQP3J Discovery agent N.A. Investigative [6]
1-methyl-1H-indole-3-carboxamide DMUKAH6 Discovery agent N.A. Investigative [7]
6-phenyl-3-(pyridin-4-yl)-1H-indole DM3UBR5 Discovery agent N.A. Investigative [8]
C4-MAD DMGA9U7 Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Amidophosphoribosyltransferase (PPAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [10]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [11]
Mycophenolic hydroxamic acid DM4YRAH Discovery agent N.A. Investigative [4]
Tiazofurin adenine dinucleotide DMEFVPH Discovery agent N.A. Investigative [5]
Mycophenolic bis(sulfonamide) DMUQP3J Discovery agent N.A. Investigative [6]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Amidophosphoribosyltransferase (PPAT) TTZFTY4 PUR1_HUMAN Inhibitor [1]
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) TTTB4UP IMDH2_HUMAN Inhibitor [1]

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 Clinical pipeline report, company report or official report of Roche (2009).
3 Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690.
4 Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycoph... Bioorg Med Chem. 2010 Nov 15;18(22):8106-11.
5 Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment. J Med Chem. 2007 Dec 27;50(26):6685-91.
6 Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase. Bioorg Med Chem. 2008 Aug 1;16(15):7462-9.
7 Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8.
8 Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships. Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42.
9 Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia. J Med Chem. 2002 Jan 31;45(3):703-12.
10 6-mercaptopurine (6-MP) induces p53-mediated apoptosis of neural progenitor cells in the developing fetal rodent brain. Neurotoxicol Teratol. 2009 Jul-Aug;31(4):198-202.
11 IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations. Br J Clin Pharmacol. 2008 Jan;65(1):69-77.