General Information of Drug (ID: DMWOBAE)

Drug Name
tetralin_urea analogue (7o) Drug Info
Synonyms
CHEMBL384701; tetralin_urea analogue (7o); 3-(3-chloro-4-fluorophenyl)-1-(7-cyano-1,2,3,4-tetrahydronaphthalen-2-yl)-1-[3-(4-methylpiperazin-1-yl)propyl]urea; 3-(3-chloro-4-fluorophenyl)-1-(7-cyano-1,2,3,4-tetrahydronaphthalen-2-yl)-1-(3-(4-methylpiperazin-1-yl)propyl)urea; SCHEMBL3990193; GTPL1319; GQGGDNLJDZHJKN-UHFFFAOYSA-N; BDBM50203352
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
11691555
TTD Drug ID
DMWOBAE

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BMS-830216 DMCW71N Obesity 5B81 Phase 1 [3]
AZD1979 DMQ1OX4 Obesity 5B81 Phase 1 [4]
PMID25522065-Compound-27 DMXN4KB N. A. N. A. Patented [5]
PMID25522065-Compound-29 DMBNAK9 N. A. N. A. Patented [5]
PMID25522065-Compound-34 DMZDIRQ N. A. N. A. Patented [5]
PMID25522065-Compound-39 DM5YMQH N. A. N. A. Patented [5]
PMID25522065-Compound-40 DMCIQ01 N. A. N. A. Patented [5]
PMID25522065-Compound-11 DM410Z6 N. A. N. A. Patented [5]
PMID25522065-Compound-50 DMBWA0V N. A. N. A. Patented [5]
PMID25522065-Compound-12 DMVKO9C N. A. N. A. Patented [5]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Melanin-concentrating hormone receptor 1 (MCHR1) TTX4RTB MCHR1_HUMAN Antagonist [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1319).
2 Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1718-21.
3 2011 Pipeline of Bristol-Myers Squibb.
4 Phase I clinical trial of AZD1979 for treating obesity. AstraZeneca plc
5 Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207.