Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWV8C6)

Drug Name

CA-4948 Drug Info

Synonyms

RWIMETUXCNDSLE-UHFFFAOYSA-N; SCHEMBL16896371; GTPL10152; CA4948; AU4948; AU-4948; example 1 [WO2015104688A1]; HY-109585; CS-0032273; 6'-Amino-N-[2-(morpholin-4-yl)-[1,3]oxazolo[4,5-b]pyridin-6-yl]-[2,3'-bipyridine]-6-carboxamide; 6-(6-aminopyridin-3-yl)-N-(2-morpholin-4-yl-[1,3]oxazolo[4,5-b]pyridin-6-yl)pyridine-2-carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Lymphoma	2A80-2A86	Phase 1	[1]

Cross-matching ID

PubChem CID: 118224238
TTD Drug ID: DMWV8C6

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Download the Complete Related Drug List

Drug(s) Targeting Renal carcinoma antigen NY-REN-64 (IRAK-4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GS-5718	DMRKU0L	Rheumatoid arthritis	FA20	Phase 2	[2]
Zabedosertib	DMEZGWP	Atopic dermatitis	EA80	Phase 2	[3]
BAY1834845	DM8V62T	Psoriasis vulgaris	EA90	Phase 1	[4]
AZD6793	DM5GRZV	Inflammation	1A00-CA43.1	Phase 1	[5]
SAR444656	DMIF2OL	Atopic dermatitis	EA80	Phase 1	[6]
Pyrazolopyrimidine and thienopyrimidine amide derivative 1	DM6TB4Z	N. A.	N. A.	Patented	[7]
Pyrazolopyrimidine and thienopyrimidine amide derivative 2	DMFUNH4	N. A.	N. A.	Patented	[7]
Indazoletriazolephenyl derivative 1	DMHJDU6	N. A.	N. A.	Patented	[7]
Indazoletriazolephenyl derivative 2	DMWZLK6	N. A.	N. A.	Patented	[7]
Indazole amide derivative 2	DMRPT5O	N. A.	N. A.	Patented	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Renal carcinoma antigen NY-REN-64 (IRAK-4)	TTKFVXR	IRAK4_HUMAN	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	IRAK4 degrader to take on innate immunity. Nat Biotechnol. 2020 Nov;38(11):1221-1223.
3	Oral IRAK4 inhibitor BAY-1834845 prevents acute respiratory distress syndrome. Biomed Pharmacother. 2022 Sep;153:113459.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Clinical pipeline report, company report or official report of AstraZeneca
6	Clinical pipeline report, company report or official report of Sanofi
7	Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32.