Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWYEDX)

Drug Name

ON-01210.Na Drug Info

Synonyms

Ex-RAD; Tyrosine kinase inhibitor (radiation protection), Onconova; ON-01210.Na (oral, radiation sickness); ON-01210.Na (oral, radiation sickness), Onconova; ON-01210.Na (sc, radiation sickness), Onconova Therapeutics

Indication

Disease Entry	ICD 11	Status	REF
Acute radiation syndrome	NF00	Phase 1	[1]
Radiation syndrome	NF00	Phase 1	[2]

Cross-matching ID

PubChem CID: 23668369
CAS Number: CAS 922139-31-9
TTD Drug ID: DMWYEDX

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting PI3K/AKT/mTOR pathway (PAm pathway)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[4]
Glypromate	DM0OX31	Neurological disorder	6B60	Phase 4	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PI3K/AKT/mTOR pathway (PAm pathway)	TTGQUFK	NOUNIPROTAC	Inhibitor	[3]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020974)
3	ON01210.Na (Ex-RAD ) mitigates radiation damage through activation of the AKT pathway. PLoS One. 2013;8(3):e58355.
4	The genomic landscape of nasopharyngeal carcinoma.Nat Genet. 2014 Aug;46(8):866-71.
5	Dendritic spine dysgenesis in Rett syndrome. Front Neuroanat. 2014; 8: 97.