Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMX0EAK)

• Drug Name: 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine Drug Info
• Synonyms: 5--MONOPHOSPHATE-9-BETA-D-RIBOFURANOSYL XANTHINE; AC1O43SS; DB02309; 5-MONOPHOSPHATE-9-BETA-D-RIBOFURANOSYL XANTHINE; [(2R,3S,4R,5R)-5-(2,6-dioxo-3,7-dihydropurin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 6323540
  TTD Drug ID: DMX0EAK

Molecule-Related Drug Atlas

Drug(s) Targeting Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9200020, Table 3, Compound 1B	DMEARS2	N. A.	N. A.	Patented	[2]
US9200020, Table 3, Compound 2B	DMXFB5Z	N. A.	N. A.	Patented	[2]
US9200020, Table 3 compound 8	DMCLHX5	N. A.	N. A.	Patented	[2]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[1]
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[1]
Pyrophosphate 2-	DMZQ75M	Discovery agent	N.A.	Investigative	[3]
Guanosine-5'-Monophosphate	DM3SLZK	Discovery agent	N.A.	Investigative	[1]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[1]
Alpha-Phosphoribosylpyrophosphoric Acid	DMT6KI7	Discovery agent	N.A.	Investigative	[3]
Carboxylic PRPP	DMCTUR1	Discovery agent	N.A.	Investigative	[1]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ)	TTBL49X	HGXR_PLAFG	Inhibitor	[1]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [2] 6-oxopurine phosphoribosyltransferase inhibitors. US9200020.
• [3] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.