Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMX1OI8)

Drug Name

ISIS 11158 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting ICAM1 messenger RNA (ICAM1 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 1570	DMJ9G23	Lleum inflammation	1A40.0	Approved	[2]
Alicaforsen	DMQ509J	Lleum inflammation	1A40.0	Phase 3	[3]
INXC-ICAM1	DMODQW0	Transplant rejection	NE84	Terminated	[4]
A-286982	DM98VFW	Discovery agent	N.A.	Investigative	[5]
ISIS 11159	DM9V6FW	Discovery agent	N.A.	Investigative	[1]
ISIS 3224	DMAFEYG	Discovery agent	N.A.	Investigative	[1]
ISIS 1931	DMBMQNI	Discovery agent	N.A.	Investigative	[2]
PIPERROLEIN B	DMRVHWZ	Discovery agent	N.A.	Investigative	[6]
ISIS 2974	DM7K19L	Discovery agent	N.A.	Investigative	[2]
Dehydropipernonaline	DMIOA9M	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	US patent application no. 5,789,573, Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2.
2	US patent application no. 6,300,491, Oligonucleotide inhibition of cell adhesion.
3	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
4	ISIS 2302. INXC ICAM1, Oligo-TCS. Drugs R D. 1999 Jan;1(1):85-6.
5	Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5269-73.
6	Alkamides from the fruits of Piper longum and Piper nigrum displaying potent cell adhesion inhibition. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4544-6.