General Information of Drug (ID: DMX2FL3)

Drug Name
Ketoprofen glucuronide Drug Info
Synonyms
Ketoprofen glucuronide; KETOPROFEN ACYL-B-D-GLUCURONIDE; 76690-94-3; DL-Ketoprofen glucuronide; (R)-Ketoprofen Glucuronide; (S)-Ketoprofen Glucuronide; CHEMBL3526739; DTXSID30998002; FT-0670648; W-203754; 1-O-[2-(3-Benzoylphenyl)propanoyl]hexopyranuronic acid; 1-(3-benzoyl-alpha-methylbenzeneacetate) beta-D-glucopyranuronic acid; beta-D-Glucopyranuronic acid, 1-(3-benzoyl-alpha-methylbenzeneacetate); 1-(3-benzoyl-alpha-methylbenzeneacetate) beta-delta-glucopyranuronic acid
Cross-matching ID
PubChem CID
131281
CAS Number
CAS 76690-94-3
TTD Drug ID
DMX2FL3
INTEDE Drug ID
DR2890

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Drug(s) Metabolized By Beta-glucuronidase (uidA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [2]
Conjugated Estrogens DMLT0E1 Dyspareunia GA12 Approved [3]
SN-38G DM2UVNB N. A. N. A. Investigative [4]
Indomethacin glucuronide DMSBENK N. A. N. A. Investigative [5]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Beta-glucuronidase (uidA) Main DME DE9RA0I BGLR_ECOLI Substrate [1]

References

1 Bacterial beta-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics. Xenobiotica. 2014 Jan;44(1):28-35.
2 Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats. Cancer Res. 1996 Aug 15;56(16):3752-7.
3 Long-term administration of conjugated estrogen and bazedoxifene decreased murine fecal beta-glucuronidase activity without impacting overall microbiome community. Sci Rep. 2018 May 25;8(1):8166.
4 Metabolism of irinotecan and its active metabolite SN-38 by intestinal microflora in rats. Oncol Rep. 2008 Oct;20(4):727-30.
5 Bidirectional interactions between indomethacin and the murine intestinal microbiota. Elife. 2015 Dec 23;4:e08973.