Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMX7WU9)

Drug Name

PB-1120 Drug Info

Synonyms

Insulin-ELP

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Helodermin-preferring VIP receptor (VIPR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PB1046	DM8MJ3F	Heart failure	BD10-BD13	Phase 2	[2]
RG-7103	DM2IDQ9	Chronic obstructive pulmonary disease	CA22	Phase 1	[3]
PACAP-27	DMB26IK	Discovery agent	N.A.	Investigative	[4]
helodermin	DMIUABO	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Helodermin-preferring VIP receptor (VIPR2)	TT4O5P0	VIPR2_HUMAN	Modulator	[1]

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References

1	Company report (PhaseBio)
2	Clinical pipeline report, company report or official report of PhaseBio Pharmaceuticals.
3	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027925)
4	A systematic comparison of intracellular cyclic AMP and calcium signalling highlights complexities in human VPAC/PAC receptor pharmacology. Neuropharmacology. 2006 Nov;51(6):1086-98.
5	Analogues of VIP, helodermin, and PACAP discriminate between rat and human VIP1 and VIP2 receptors. Ann N Y Acad Sci. 1998 Dec 11;865:247-52.