Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXDTPL)

Drug Name

PMID22902653C30 Drug Info

Synonyms

GTPL8118; BDBM50390789

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting LIM domain kinase-2 (LIMK-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID22902653C31	DMWVTAE	Discovery agent	N.A.	Investigative	[2]
PMID22902653C35	DMLVKPG	Discovery agent	N.A.	Investigative	[2]
PMID19831390C14	DMIECOF	Discovery agent	N.A.	Investigative	[3]
PMID19831390C22m	DM8T6VG	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Targeting Testis-specific kinase 2 (TESK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID22902653C31	DMWVTAE	Discovery agent	N.A.	Investigative	[2]
PMID22902653C35	DMLVKPG	Discovery agent	N.A.	Investigative	[2]
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Drug(s) Targeting Testis-specific kinase 1 (TESK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID22902653C31	DMWVTAE	Discovery agent	N.A.	Investigative	[2]
PMID22902653C35	DMLVKPG	Discovery agent	N.A.	Investigative	[2]
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Drug(s) Targeting LIM domain kinase-1 (LIMK-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RKI-1447	DMGTAWC	Discovery agent	N.A.	Investigative	[4]
PMID22902653C31	DMWVTAE	Discovery agent	N.A.	Investigative	[2]
PMID22902653C35	DMLVKPG	Discovery agent	N.A.	Investigative	[2]
PMID19831390C14	DMIECOF	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
LIM domain kinase-1 (LIMK-1)	TTWL9TY	LIMK1_HUMAN	Inhibitor	[2]
LIM domain kinase-2 (LIMK-2)	TTASMD8	LIMK2_HUMAN	Inhibitor	[2]
Testis-specific kinase 1 (TESK1)	TTWKT3Y	TESK1_HUMAN	Inhibitor	[2]
Testis-specific kinase 2 (TESK2)	TTRMD8U	TESK2_HUMAN	Inhibitor	[2]

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References

1	Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. J Biol Chem. 2001 Aug 17;276(33):31449-58.
2	Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8.
3	Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma. J Med Chem. 2009 Nov 12;52(21):6515-8.
4	Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm. 2012 Jun 1;3(6):699-709.