Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXF32O)

Drug Name
PMID21823616C22 Drug Info
Synonyms ILK-IN-1; OSU-T315; 1333146-24-9; GTPL8116; BCP23690; ZINC72120050; BDBM50353484; AKOS030257532; CS-4936; HY-18676; SC-98385
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
51051074
TTD Drug ID
DMXF32O

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Integrin-linked protein kinase 1 (ILK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
US8754233, 4-(5-Fluoro-6-methoxy-benzothiazol-2-yl)-5-(2-fluoro-phenyl)-2H-pyrazol-3-ylamine DMJY0CD N. A. N. A. Patented [3]
US8754233, (4-Benzothiazol-2-yl-1H-pyrazol-3-yl)-[2-(1H-imidazol-4-yl)-ethyl]-amine DMSYD3X N. A. N. A. Patented [3]
US8754233, 2-(3-Amino-1H-pyrazol-4-yl)-5-fluoro-benzothiazole-6-sulfonic acid amide DMJPQNH N. A. N. A. Patented [3]
MST-400 DMUKWJ2 Solid tumour/cancer 2A00-2F9Z Investigative [4]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Integrin-linked protein kinase 1 (ILK) TT7ALZG ILK_HUMAN Inhibitor [2]

References

1 Integrin-linked kinase overexpression and its oncogenic role in promoting tumorigenicity of hepatocellular carcinoma. PLoS One. 2011 Feb 9;6(2):e16984.
2 Identification and characterization of a novel integrin-linked kinase inhibitor. J Med Chem. 2011 Sep 22;54(18):6364-74.
3 Pyrazolylbenzothiazole derivatives and their use as therapeutic agents. US8754233.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2041).