Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXY980)

Drug Name
VU0364770 Drug Info
Synonyms
61350-00-3; VU 0364770; VU0364770; N-(3-chlorophenyl)picolinamide; N-(3-chlorophenyl)-2-pyridinecarboxamide; N-(3-chlorophenyl)pyridine-2-carboxamide; CHEMBL556667; 2-Pyridinecarboxamide, N-(3-chlorophenyl)-; AC1LHD0L; GTPL6234; SCHEMBL2530324; cid_836002; KS-00001CNQ; CTK2E1861; DTXSID00356877; MolPort-002-826-420; ZINC362766; HMS3651P19; EX-A1099; BCP19097; s2862; 2565AH; BDBM50293743; AKOS003020541; CS-6072; KB-276111; HY-100588; VU-0364770; N-(3-chloro-phenyl)-pyridine-2-carboxamide; SW219537-1
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
836002
CAS Number
CAS 61350-00-3
TTD Drug ID
DMXY980

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Metabotropic glutamate receptor 4 (mGluR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
DT-1687 DMU2GP4 Parkinson disease 8A00.0 Phase 2 [3]
L-serine-O-phosphate DMTJ1NH Discovery agent N.A. Investigative [4]
L-CCG-I DMPZ8XH Discovery agent N.A. Investigative [5]
MAP4 DMUCE93 Discovery agent N.A. Investigative [6]
MPPG DMJHQ9T Discovery agent N.A. Investigative [6]
L-AP4 DMPJFGI Discovery agent N.A. Investigative [6]
PHCCC DMNJY79 Discovery agent N.A. Investigative [7]
2-methyl-6-(phenylethynyl)pyridine DMVQK4Y Discovery agent N.A. Investigative [8]
LSP4-2022 DMBWHGP Discovery agent N.A. Investigative [9]
(S)-3,4-DCPG DMG5BUA Discovery agent N.A. Investigative [10]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Metabotropic glutamate receptor 4 (mGluR4) TTICZ1O GRM4_HUMAN Modulator (allosteric modulator) [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6234).
2 The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. J Pharmacol Exp Ther. 2012 Feb;340(2):404-21.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 292).
4 Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor. Neuroreport. 1993 Sep;4(9):1099-101.
5 Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells. Br J Pharmacol. 1992 Oct;107(2):539-43.
6 Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor. J Biol Chem. 1999 Apr 9;274(15):10008-13.
7 (-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection. Neuropharmacology. 2003 Dec;45(7):895-906.
8 Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br J Pharmacol. 2003 Mar;138(6):1026-30.
9 A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential. FASEB J. 2012 Apr;26(4):1682-93.
10 (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology. 2001 Mar;40(3):311-8.