Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYBHIR)

• Drug Name: IBI-20089 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Diabetic macular edema	9B71.02	Phase 1	[1]

• Cross-matching ID: TTD Drug ID: DMYBHIR

Molecule-Related Drug Atlas

Drug(s) Targeting Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[2]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[3]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[4]
Fluticasone	DMGCSVF	Allergic rhinitis	CA08.0	Approved	[5]
Betamethasone Valerate	DMMIAXO	Dermatological disease	DA24.Y	Approved	[3]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[3]
Deflazacort	DMV0RNS	Duchenne dystrophy	8C70	Approved	[3]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[6]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[7]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[8]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucocorticoid receptor (NR3C1)	TTYRL6O	GCR_HUMAN	Agonist	[1]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cells. Exp Hematol. 2009 May;37(5):559-72.
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [4] Aldosterone (mineralocorticoid) equivalent to prednisolone (glucocorticoid) in reversing hearing loss in MRL/MpJ-Fas1pr autoimmune mice. Laryngoscope. 2000 Nov;110(11):1902-6.
• [5] Fluticasone furoate nasal spray in allergic rhinitis. Drugs Today (Barc). 2008 Apr;44(4):251-60.
• [6] Cytochromes P450 (CYP) in the Poeciliopsis lucida hepatocellular carcinoma cell line (PLHC-1): dose- and time-dependent glucocorticoid potentiation of CYP1A induction without induction of CYP3A. ArchBiochem Biophys. 1996 May 1;329(1):113-22.
• [7] PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide. Eur J Pharm Sci. 2009 Mar 2;36(4-5):565-71.
• [8] The glucocorticoid agonist activities of mifepristone (RU486) and progesterone are dependent on glucocorticoid receptor levels but not on EC50 values. Steroids. 2007 Jun;72(6-7):600-8.