Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYI87T)

Drug Name
N-ethylhistamine Drug Info
Synonyms
479408-49-6; 2-(1-ethyl-1h-imidazol-4-yl)ethanamine; 1-ETHYL-1H-IMIDAZOLE-4-ETHANAMINE; 2-(1-Ethyl-1H-imidazol-4-yl)ethan-1-amine; N-ethylhistamine; 2-(1-Ethyl-1H-imidazol-4-yl)ethylamine; CHEMBL46296; SCHEMBL589342; GTPL1271; CTK4J0489; DTXSID90658170; LIXGKSRWGHVUHT-UHFFFAOYSA-N; ZINC29412524; 2-(1-ethylimidazol-4-yl)ethanamine; AKOS006337816
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44292270
CAS Number
CAS 479408-49-6
TTD Drug ID
DMYI87T

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Histamine H4 receptor (H4R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PF-3893787 DMC2FAL Atopic dermatitis EA80 Phase 2 [3]
JNJ-38518168 DM9UMIO Plaque psoriasis EA90.0 Phase 2 [4]
UR-63325 DME6X27 Allergic rhinitis CA08.0 Phase 2 [5]
Thioperamide DM8S593 Cognitive impairment 6D71 Terminated [6]
2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole DMZVBPG Discovery agent N.A. Investigative [7]
impromidine DMTDRPM Discovery agent N.A. Investigative [8]
burimamide DMZ2VYG Discovery agent N.A. Investigative [9]
Imetit DMMJ6NS Discovery agent N.A. Investigative [10]
[125I]iodophenpropit DMN4ABU Discovery agent N.A. Investigative [11]
(R)-alpha-methylhistamine DMKAW4P Discovery agent N.A. Investigative [12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H4 receptor (H4R) TTXJ178 HRH4_HUMAN Agonist [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1271).
2 Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. Br J Pharmacol. 2006 Apr;147(7):744-54.
3 Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6596-602.
4 The histamine H4 receptor: from orphan to the clinic. Front Pharmacol. 2015; 6: 65.
5 Azines as histamine H4 receptor antagonists. Front Biosci (Schol Ed). 2012 Jan 1;4:967-87.
6 Role of histamine in short- and long-term effects of methamphetamine on the developing mouse brain. J Neurochem. 2008 Nov;107(4):976-86.
7 Synthesis and structure-activity relationships of N-aryl-piperidine derivatives as potent (partial) agonists for human histamine H3 receptor. Bioorg Med Chem. 2010 Jul 15;18(14):5441-8.
8 Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first pote... J Pharmacol Exp Ther. 2005 Sep;314(3):1310-21.
9 Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. J Pharmacol Exp Ther. 2001 Oct;299(1):121-30.
10 Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors. J Neurophysiol. 2006 Apr;95(4):2492-500.
11 Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening. J Med Chem. 2008 Jun 12;51(11):3145-53.
12 Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6.