Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYNMDP)

• Drug Name: Tocainide Drug Info
• Synonyms: Taquidil; Tocainida; Tocainidum; Tonocard; Astra W 36095; Tocainida [INN-Spanish]; Tocainidum [INN-Latin]; W-36095; Tocainide (USAN/INN); Tocainide [USAN:BAN:INN]; Alanyl-2,6-xylidide; N-(2,6-dimethylphenyl)alaninamide; (-)-2-Amino-N-(2,6-dimethylphenyl)propanamide; 2-AMINO-N-(2,6-DIMETHYLPHENYL)PROPANAMIDE; 2-Amino-2',6'-propionoxylidide; 2-Amino-N-(2,6-dimethylphenyl)propionamid

Indication

Disease Entry	ICD 11	Status	REF
Ventricular arrhythmias	BC71	Approved	[1]

• Therapeutic Class: Antiarrhythmic Agents
• Cross-matching ID:
  PubChem CID: 38945
  ChEBI ID: CHEMBL9611
  CAS Number: CAS 41708-72-9
  TTD Drug ID: DMYNMDP
  INTEDE Drug ID: DR1607

Molecule-Related Drug Atlas

Drug(s) Targeting E3 ubiquitin-protein ligase COP1 (RFWD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[2]
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[2]
Propafenone	DMPIBJK	Tachyarrhythmias	BC71	Approved	[2]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[2]
Barucainide	DMTMS3L	Heart arrhythmia	BC65	Terminated	[5]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[6]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[7]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[8]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[10]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[12]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[13]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[14]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[15]

Drug(s) Affected By Sodium channel protein type 5 subunit alpha (SCN5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[4]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[16]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[17]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[18]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[21]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[24]

Drug(s) Affected By Potassium voltage-gated channel subfamily E member 1 (KCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Pentobarbital	DMFNH7L	Brain ischaemia	8B1Z	Approved	[27]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[4]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[4]
Diltiazem	DMAI7ZV	Angina pectoris	BA40	Approved	[4]
Sotalol	DML60TN	Sinus rhythm disorder	BC9Y	Approved	[4]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[4]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[4]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[4]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
E3 ubiquitin-protein ligase COP1 (RFWD2)	TT05DLS	COP1_HUMAN	Modulator	[2]
Voltage-gated sodium channel (Nav)	TTIG65Q	NOUNIPROTAC	Modulator	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 1A2 (CYP1A2) Main DME	DEJGDUW	CP1A2_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Potassium voltage-gated channel subfamily E member 1 (KCNE1)	OTZNQUW9	KCNE1_HUMAN	Drug Response	[4]
Sodium channel protein type 5 subunit alpha (SCN5A)	OTGYZWR6	SCN5A_HUMAN	Drug Response	[4]

References

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