Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYS6DB)

Drug Name
18alpha-Glycyrrhetic acid Drug Info
Synonyms
18a-Glycyrrhetic acid; 18a-glycyrrhetinic acid; 1449-05-4; CHEMBL378653; 18ss -Glycyrrhetinic acid; SCHEMBL18539; MolPort-027-835-537; BDBM50185128; AKOS016009638; DS-5150; 3A-Hydroxy-11-oxo-18ss20ss -olean-12-en-29-oic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
12193680
CAS Number
CAS 471-53-4
TTD Drug ID
DMYS6DB

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting PTPN1 messenger RNA (PTPN1 mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [2]
TRYPAN BLUE DM4NTMO Ophthalmic surgery injury PK97 Approved [3]
URSOLIC ACID DM4SOAW Metabolic syndrome x 5C50-5D2Z Phase 2 [4]
ISIS 113715 DMUPD4G Type-2 diabetes 5A11 Phase 2 [5]
ISIS-PTP1Brx DMJGVXT Type-2 diabetes 5A11 Phase 2 [6]
ERTIPROTAFIB DMJXEV7 Type-2 diabetes 5A11 Terminated [7]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [8]
B-Octylglucoside DMMO75G Discovery agent N.A. Investigative [8]
2-Methyl-2,4-Pentanediol DMD45CU Discovery agent N.A. Investigative [8]
Double Oxidized Cysteine DM6TU84 Discovery agent N.A. Investigative [8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PTPN1 messenger RNA (PTPN1 mRNA) TTELIN2 PTN1_HUMAN Inhibitor [1]

References

1 Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6.
2 Periodinates: a new class of protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):353-6.
3 Evans Blue and other dyes as protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1923-6.
4 Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9.
5 Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
6 Clinical pipeline report, company report or official report of ISIS Pharmaceuticals.
7 2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5357-60.
8 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.