Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYUP6G)

Drug Name	PMID27336223-Compound-10 Drug Info
Cross-matching ID	PubChem CID 5381 ChEBI ID CHEBI:32184 CAS Number CAS 118292-40-3 TTD Drug ID DMYUP6G

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Retinoic acid receptor beta (RARB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[2]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[3]
PMID27336223-Compound-8	DM460D1	N. A.	N. A.	Patented	[1]
PMID27336223-Compound-7	DM9QM6I	N. A.	N. A.	Patented	[1]
CD666	DMC8X9Y	Discovery agent	N.A.	Investigative	[4]
AGN193109	DMC0YOE	Discovery agent	N.A.	Investigative	[5]
AC55649	DM4JNY9	Discovery agent	N.A.	Investigative	[6]
BMS641	DMRT7G3	Discovery agent	N.A.	Investigative	[7]
AC261066	DMSKE1I	Discovery agent	N.A.	Investigative	[6]
TTNPB	DMSABD0	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Retinoic acid receptor beta (RARB)	TTISP28	RARB_HUMAN	Agonist	[1]

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References

1	Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.Expert Opin Ther Pat. 2016 Aug;26(8):957-71.
2	Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):30-4.
3	Tamibarotene: a candidate retinoid drug for Alzheimer's disease. Biol Pharm Bull. 2012;35(8):1206-12.
4	Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun. 1992 Jul 31;186(2):977-83.
5	Therapeutic applications for ligands of retinoid receptors. Curr Pharm Des. 2000 Jan;6(1):25-58.
6	Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist. J Med Chem. 2005 Dec 1;48(24):7517-9.
7	Rational design of RAR-selective ligands revealed by RARbeta crystal stucture. EMBO Rep. 2004 Sep;5(9):877-82.
8	9-cis-retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6117-22.