Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZ2LPO)

Drug Name
CD564 Drug Info
Synonyms
cd564; CHEMBL309282; 110952-26-6; 6-(5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)naphthalene-2-carboxylic acid; 2-Naphthalenecarboxylicacid, 6-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]-; 1fcy; ACMC-20mdu5; AC1L1E1W; SCHEMBL2391376; CTK0I1187; BDBM31886; DTXSID60274381; DB02741; 6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthoyl)-2-naphthoic acid; 6-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]naphthalene-2-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
2605
CAS Number
CAS 110952-26-6
TTD Drug ID
DMZ2LPO

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Retinoic acid receptor gamma (RARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [2]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [3]
Trifarotene DMOL793 Acne vulgaris ED80 Approved [4]
Tazarotene DM8SMD1 Acne vulgaris ED80 Approved [5]
Palovarotene DMAD2OZ Fibrodysplasia ossificans progressiva FB31.1 Approved [6]
PMID27336223-Compound-13 DMSZLYD N. A. N. A. Patented [7]
PMID27336223-Compound-12 DMT4P7K N. A. N. A. Patented [7]
PMID27336223-Compound-14 DMC41MA N. A. N. A. Patented [7]
PMID27336223-Compound-11 DMBN6KU N. A. N. A. Patented [7]
PMID27336223-Compound-15 DMIYCFE N. A. N. A. Patented [7]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Retinoic acid receptor gamma (RARG) TT1Q3IE RARG_HUMAN Inhibitor [1]

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 Targacept active conformation search: a new method for predicting the conformation of a ligand bound to its protein target. J Med Chem. 2004 Dec 30;47(27):6831-9.
3 Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):30-4.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
5 Recent developments in receptor-selective retinoids. Curr Pharm Des. 2000 Jun;6(9):919-31.
6 Randomised controlled trial for emphysema with a selective agonist of the gamma-type retinoic acid receptor. Eur Respir J. 2012 Aug;40(2):306-12.
7 Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.Expert Opin Ther Pat. 2016 Aug;26(8):957-71.