General Information of Drug (ID: DMZ8WMA)

Drug Name
3-bicyclo[2.2.1]hept-2-yl-benzene-1,2-diol Drug Info
Synonyms
1,2-benzenediol,3-bicyclo[2.2.1]hept-2-yl-; 462606-73-1; AC1MXF8P; 3-bicyclo[2.2.1]hept-2-yl-benzene-1,2-diol; Oprea1_604715; GTPL2569; CTK8I7953; AKOS027407656; KB-148826; 3-(3-bicyclo[2.2.1]heptanyl)benzene-1,2-diol
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
3764681
TTD Drug ID
DMZ8WMA

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
[14C]TEA DM6SFYH Discovery agent N.A. Investigative [3]
DABCO-C16 DMN3GTF Discovery agent N.A. Investigative [4]
RY796 DMW4850 Discovery agent N.A. Investigative [5]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated potassium channel Kv2.1 (KCNB1) TT5OEKU KCNB1_HUMAN Blocker (channel blocker) [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2569).
2 Novel neuroprotective K+ channel inhibitor identified by high-throughput screening in yeast. Mol Pharmacol. 2004 Jan;65(1):214-9.
3 Modulation of Kv2.1 channel gating and TEA sensitivity by distinct domains of SNAP-25. Biochem J. 2006 Jun 1;396(2):363-9.
4 1,4-Diazabicyclo[2.2.2]octane derivatives: a novel class of voltage-gated potassium channel blockers. Mol Pharmacol. 2006 Mar;69(3):718-26.
5 Identification of novel and selective Kv2 channel inhibitors. Mol Pharmacol. 2011 Dec;80(6):959-64.