Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZ9BMU)

Drug Name
Colistimethate Drug Info
Synonyms
Colimicina; Colimyscine; Colimycin M; Colistimethale Sodium; Colistimethate sodium; Colistin Sulfomethate; Colistin methanesulfonate sodium salt; Colistin sodium methanesulfonate; Colistin sodium methanesulfonate from bacillus colistinus; Colistin sulfomethate sodium; Colistinemethanesulfonate sodique; Colistrimethate sodium; Colymycin M; Pentasodium colistinmethanesulfonate; Sodium colistimethate; Sodium colistin methanesulfonate; Sodium colistinemethanesulfonate; W 1929; Colistimethate sodium [USAN:INN]; Colistinmethanesulfonic acid, sodium salt; Coly-Mycin M; Coly-Mycin M Parenteral; Coly-mycin injectable
Indication
Disease Entry ICD 11 Status REF
Respiratory tract infection CA45 Approved [1]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
216258
CAS Number
CAS 8068-28-8
TTD Drug ID
DMZ9BMU

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bacterial Dihydropteroate synthetase (Bact folP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [3]
Sulfadiazine DMTW3R8 Rheumatic fever 1B40-1B42 Approved [4]
Doripenem DM9UCJK Cholecystitis Approved [5]
Colistin DMMD9QE Pseudomonas infection 1B92 Approved [2]
Sulphadoxine DMZI2UF Malaria 1F40-1F45 Approved [6]
Sulfisoxazole DMXLT8C Acute otitis media AB00 Approved [7]
Sulfapyridine DMIUYFH Dermatitis herpetiformis EB44 Approved [8]
Gramicidin D DMPT74U Bacterial infection 1A00-1C4Z Approved [9]
Oritavancin DM28D05 Bacterial infection 1A00-1C4Z Approved [5]
Faropenem DMX7A5V Gram-positive bacterial infection 1B74-1G40 Approved [5]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Dihydropteroate synthetase (Bact folP) TT4ILYC DHPS_ECOLI Binder [2]

References

1 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 064216.
2 Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria. Ann Pharmacother. 1999 Sep;33(9):960-7.
3 In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs. Antimicrob Agents Chemother. 1995 Apr;39(4):948-52.
4 Sulfadiazine/hydroxypropyl-beta-cyclodextrin host-guest system: Characterization, phase-solubility and molecular modeling. Bioorg Med Chem. 2008 May 15;16(10):5788-94.
5 Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
6 The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
7 Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob Agents Chemother. 1995 Aug;39(8):1756-63.
8 A confirmatory method for the simultaneous extraction, separation, identification and quantification of Tetracycline, Sulphonamide, Trimethoprim an... J Chromatogr A. 2009 Nov 13;1216(46):8110-6.
9 Structures of gramicidins A, B, and C incorporated into sodium dodecyl sulfate micelles. Biochemistry. 2001 Oct 2;40(39):11676-86.