Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZEPFJ)

Drug Name
Demeclocycline Drug Info
Synonyms
Bioterciclin; Clortetrin; DMCT; DMCTC; Declomycin; Deganol; Demeclociclina; Demeclocyclinum; Demeclor; Demethylchlorotetracycline; Demethylchlortetracyclin; Demethylchlortetracycline; Demethylchlortetracyclinum; Demetraclin; Diuciclin; Ledermycin; Methylchlorotetracycline; Mexocine; Novotriclina; Perciclina; Sumaclina; Demeclocycline Monohydrochloride; Demethylchlortetracycline base; Ledermycin hydrochloride; RP 10192; DMCT (antibiotic); Declomycin (TN); Declostatin (TN); Demeclociclina [INN-Spanish]; Demeclocycline (USP); Demeclocycline [USAN:BAN]; Demeclocyclinum [INN-Latin]; Demethylchlortetracycline (JAN); Ledermycin (TN); Tri-demethylchlortetracycline; [4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-7-chloro-4-(dimethylamino)1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide; (2E)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (2E,4S,4aS,5aS,6R,12aR)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (2E,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (2Z,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide; 2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; 6-Demethyl-7-chlorotetracycline; 6-Demethyl-7-chlortetracycline; 6-Demethylchlorotetracycline; 6-Demethylchlortetracycline; 6-Demetil-7-clorotetraciclina; 6-Demetil-7-clorotetraciclina [Italian]; 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide; 7-Chloro-4-dimethylamino-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide; 7-Chloro-6-demethyltetracycline
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [1]
Actinomycosis Approved [2]
Acute gonococcal cervicitis Approved [2]
Bronchitis CA20 Approved [1]
Brucellosis Approved [2]
Chancroid Approved [2]
Lyme disease 1C1G Approved [1]
Lymphogranuloma venereum Approved [2]
Ornithosis Approved [2]
Pneumonia CA40 Approved [2]
Q fever Approved [2]
Relapsing fever Approved [2]
Rickettsialpox Approved [2]
Rocky mountain spotted fever Approved [2]
Staphylococcus aureus infection Approved [2]
Syphilis Approved [2]
Trachoma Approved [2]
Typhus Approved [2]
Urinary tract infection GC08 Approved [2]
Yaws Approved [2]
Sinusitis CA0A.Z Investigative [2]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
54680690
ChEBI ID
CHEBI:4392
CAS Number
CAS 127-33-3
TTD Drug ID
DMZEPFJ
ACDINA Drug ID
D00178

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tetracycline DMZA017 Acne vulgaris ED80 Approved [4]
Framycetin DMF8DNE Acute liver failure DB91 Approved [5]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [6]
Amikacin DM5PDRB Bacteremia 1A73 Approved [7]
Clomocycline DM0ZRMQ Bacterial infection 1A00-1C4Z Approved [8]
Spectinomycin DM0MQ35 Acute gonococcal cervicitis Approved [9]
Paromomycin DM1AGXN Amoebiasis 1A36 Approved [10]
Lymecycline DMOMLHJ Bacterial infection 1A00-1C4Z Approved [11]
Rolitetracycline DMBR5Q7 Acne vulgaris ED80 Approved [12]
Meclocycline DMSFQ8I Bacterial infection 1A00-1C4Z Approved [3]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) TTQ8KVI F4NA87_STAAU Binder [3]

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Demeclocycline FDA Label
3 Detection of tetracycline resistance genes by PCR methods. Methods Mol Biol. 2004;268:3-13.
4 The glycylcyclines: a comparative review with the tetracyclines. Drugs. 2004;64(1):63-88.
5 Characterization of a 30S ribosomal subunit assembly intermediate found in Escherichia coli cells growing with neomycin or paromomycin. Arch Microbiol. 2008 May;189(5):441-9.
6 Ribosomal resistance in the gentamicin producer organism Micromonospora purpurea. Antimicrob Agents Chemother. 1982 Aug;22(2):231-6.
7 Bacterial resistance to aminoglycosides and beta-lactams: the Tn1331 transposon paradigm. Front Biosci. 2000 Jan 1;5:D20-9.
8 Molecular dynamics simulations of the 30S ribosomal subunit reveal a preferred tetracycline binding site. J Am Chem Soc. 2008 Jan 30;130(4):1114-5.
9 Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature. 2000 Sep 21;407(6802):340-8.
10 Aminoglycoside association pathways with the 30S ribosomal subunit. J Phys Chem B. 2009 May 21;113(20):7322-30.
11 Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
12 Reversed-phase high-performance liquid chromatography coupled to ultraviolet and electrospray time-of-flight mass spectrometry on-line detection fo... J Chromatogr A. 2008 Jun 27;1195(1-2):107-16.