Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZG7TH)

Drug Name
[(3-Bromophenyl)-p-tolyl-ketone]thiosemicarbazone Drug Info
Synonyms CHEMBL590497; [(3-Bromophenyl)-p-tolyl-ketone]thiosemicarbazone
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
46232967
TTD Drug ID
DMZG7TH

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Cathepsin L (CTSL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
KGP94 DM2NZ6K Coagulation defect 3B10.0 Clinical trial [2]
PMID27998201-Compound-12 DM8QZNC Bone cancer 2B5Z Patented [3]
PMID27998201-Compound-5 DMVZ0ND Chronic obstructive pulmonary disease CA22 Patented [3]
PMID27998201-Compound-9 DM1JOZN Rheumatoid arthritis FA20 Patented [3]
PMID25399719-Compound-17 DMRXKJZ N. A. N. A. Patented [4]
PMID27998201-Compound-17 DMAZVHJ Hair loss ED70 Patented [3]
Phenylalanine derivative 1 DMVYP8K Glioma 2A00.0 Patented [3]
PMID27998201-Compound-7 DMU4QYR Abdominal aortic aneurysm BD50.4 Patented [3]
PMID27998201-Compound-6 DM0LGTY N. A. N. A. Patented [3]
PMID27998201-Compound-1 DM5QH4C Coronavirus infection 1D92 Patented [3]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Cathepsin B (CTSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID27998201-Compound-12 DM8QZNC Bone cancer 2B5Z Patented [3]
PMID27998201-Compound-5 DMVZ0ND Chronic obstructive pulmonary disease CA22 Patented [3]
PMID27998201-Compound-9 DM1JOZN Rheumatoid arthritis FA20 Patented [3]
PMID27998201-Compound-17 DMAZVHJ Hair loss ED70 Patented [3]
PMID27998201-Compound-11 DMTV5NU Metastatic cancer 2D50-2E2Z Patented [3]
PMID27998201-Compound-2 DMMAE3C Alzheimer disease 8A20 Patented [3]
PMID27998201-Compound-22 DMS9QA7 Alzheimer disease 8A20 Patented [3]
PMID27998201-Compound-13 DMZHIM8 Hepatic fibrosis DB93.0 Patented [3]
Dimethoxybenzylidene-2-thio-imidazole-4-one derivative 1 DMZ4B3W Cerebral ischemia 8B11 Patented [3]
PMID27998201-Compound-24 DM25BNZ Glioma 2A00.0 Patented [3]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cathepsin B (CTSB) TTF2LRI CATB_HUMAN Inhibitor [1]
Cathepsin L (CTSL) TT36ETB CATL1_HUMAN Inhibitor [1]

References

1 Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1415-9.
2 Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6610-5.
3 Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.
4 An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31.