Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZQ2DK)

Drug Name

AMG 986 Drug Info

Synonyms

DOMQFIFVDIAOOT-ROUUACIJSA-N; UNII-4B8REJ8ZGY; 4B8REJ8ZGY; Azelaprag; Azelaprag [INN]; azelaprag (proposed INN); AMG986; SCHEMBL18247065; GTPL10061; AMG-986; 2049980-18-7; example 263 [WO2016187308A1]; (2S,3R)-N-[4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-1,2,4-triazol-3-yl]-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide; 2-Pyrimidineethanesulfonamide, N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl)-alpha,beta,5-trimethyl-, (alphaS,betaR)-

Indication

Disease Entry	ICD 11	Status	REF
Heart failure	BD10-BD13	Phase 1	[1]

Cross-matching ID

PubChem CID: 122702529
CAS Number: CAS 2049980-18-7
TTD Drug ID: DMZQ2DK

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Apelin receptor (APLNR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
apelin-13	DM2CKUZ	Discovery agent	N.A.	Investigative	[2]
ML221	DM3OEP4	Discovery agent	N.A.	Investigative	[3]
ML233	DM8CIE4	Discovery agent	N.A.	Investigative	[4]
E339-3D6	DMGPRT7	Discovery agent	N.A.	Investigative	[5]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apelin receptor (APLNR)	TTJ8E43	APJ_HUMAN	Agonist	[1]

------------------------------------------------------------------------------------

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Structural and functional study of the apelin-13 peptide, an endogenous ligand of the HIV-1 coreceptor, APJ. Biochemistry. 2003 Sep 2;42(34):10163-8.
3	Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6656-60.
4	Functional Agonists of the Apelin (APJ) Receptor. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010.
5	Identification and pharmacological properties of E339-3D6, the first nonpeptidic apelin receptor agonist. FASEB J. 2010 May;24(5):1506-17.