General Information of Drug (ID: DMZUAH2)

Drug Name
ASP-4901 Drug Info
Indication
Disease Entry ICD 11 Status REF
Genitourinary disease GA0Z-GC8Z Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMZUAH2

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Drug(s) Targeting Phosphodiesterase 9 (PDE9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PF-4447943 DM81D4I Alzheimer disease 8A20 Phase 2 [3]
E2027 DMK8SY6 Lewy body dementia 6D82 Phase 2 [4]
BI-409306 DMJFDS0 Alzheimer disease 8A20 Phase 2 [5]
IMR-687 DM15MRZ Sickle-cell disorder 3A51 Phase 2 [6]
CRD-740 DMRTX0K Heart failure BD10-BD13 Phase 2 [7]
TT-00920 DMP6G0P Heart failure BD10-BD13 Phase 1 [8]
SCH51866 DMCWSJP Discovery agent N.A. Investigative [9]
PF-4181366 DMC8G4S Cognitive impairment 6D71 Investigative [10]
⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Phosphodiesterase 9 (PDE9) TTZOEBC PDE9A_HUMAN Inhibitor [2]

References

1 ClinicalTrials.gov (NCT02038868) A Study to Evaluate the Efficacy and Safety of ASP4901 in Patients With Benign Prostate Hyperplasia. U.S. National Institutes of Health.
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033070)
3 A multicenter, double-blind, placebo-controlled trial of the PDE9A inhibitor, PF-04447943, in Alzheimer's disease. Curr Alzheimer Res. 2014;11(5):413-21.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Clinical pipeline report, company report or official report of Boehringer Ingelheim pipeline.
6 Clinical pipeline report, company report or official report of Imara.
7 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
8 Clinical pipeline report, company report or official report of TransThera Biosciences
9 Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase. J Biol Chem. 1998 Jun 19;273(25):15559-64.
10 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1309).