Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM01HLX)

Drug Name
GR-127935 Drug Info
Synonyms
148672-13-3; GR 127935; GR-127935; N-(4-Methoxy-3-(4-methylpiperazin-1-yl)phenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide; GR127935; UNII-2LLH6CEB40; 2'-Methyl-4'-(5-methyl-(1,2,4)-oxadiazol-3-yl)biphenyl-4-carboxylic acid (4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)amide; 2LLH6CEB40; CHEMBL15928; GR 127935 hydrochloride hydrate; N-[4-METHOXY-3-(4-METHYLPIPERAZIN-1-YL)-PHENYL]-4-[2-METHYL-4-(5-METHYL-1,2,4-OXADIAZOL-3-YL)PHENYL]BENZAMIDE; CHEBI:64114; GR 127935 HCl; C29H31N5O3
Cross-matching ID
PubChem CID
107780
ChEBI ID
CHEMBL15928
CAS Number
CAS 148672-13-3
TTD Drug ID
D06DZI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.64 0.00e+0 19/20 (95%) MSMO1;SQLE;DHCR24;...
Terpenoid backbone biosynthesis 2.14 0.00e+0 18/22 (81.82%) HMGCS1;ACAT2;FDPS;...
PPAR signaling pathway 2.14 0.00e+0 66/74 (89.19%) SCD;HMGCS1;FADS2;...
Biosynthesis of unsaturated fatty acids 2.03 6.70e-3 21/27 (77.78%) SCD;FADS2;FADS1;...
Bladder cancer 2.02 5.36e-3 40/41 (97.56%) CDKN1A;VEGFA;SRC;...
Complement and coagulation cascades 2.02 4.47e-3 76/85 (89.41%) SERPINA1;PLAT;F5;...
Ascorbate and aldarate metabolism 1.99 5.74e-3 15/30 (50%) UGT2B28;ALDH2;GUSB;...
Bile secretion 1.93 8.38e-3 68/90 (75.56%) GNAS;LDLR;HMGCR;...
Butanoate metabolism 1.88 1.79e-2 23/28 (82.14%) HMGCS1;ACAT2;HMGCS2;...
Lysosome 1.85 2.68e-2 115/128 (89.84%) TPP1;NPC1;NEU1;...
Regulation of lipolysis in adipocytes 1.84 2.68e-2 52/55 (94.55%) GNAS;IRS2;FABP4;...
Synthesis and degradation of ketone bodies 1.84 2.46e-2 9/10 (90%) HMGCS1;ACAT2;HMGCS2
MicroRNAs in cancer 1.83 2.89e-2 146/310 (47.1%) DDIT4;IRS2;CDKN1A;...
Salivary secretion 1.82 2.97e-2 76/93 (81.72%) GNAS;CST3;CST1;...
Autophagy 1.79 3.22e-2 113/169 (66.86%) DDIT4;IRS2;SQSTM1;...
Ferroptosis 1.78 3.02e-2 36/41 (87.8%) HMOX1;SLC7A11;SLC39A8;...
Gastric acid secretion 1.78 2.84e-2 63/76 (82.89%) GNAS;CALML5;ITPR2;...
mTOR signaling pathway 1.76 3.28e-2 114/154 (74.03%) DDIT4;RRAGD;RRAGC;...
Pantothenate and CoA biosynthesis 1.76 3.10e-2 14/21 (66.67%) PANK3;ENPP1;BCAT1;...
Parathyroid hormone synthesis, secretion and action 1.75 3.42e-2 98/106 (92.45%) GNAS;CDKN1A;MAFB;...
Ovarian steroidogenesis 1.73 4.02e-2 41/51 (80.39%) GNAS;LDLR;HSD17B7;...
Notch signaling pathway 1.72 4.51e-2 49/59 (83.05%) NCOR2;CTBP2;CREBBP;...
Aldosterone synthesis and secretion 1.71 4.43e-2 85/98 (86.73%) GNAS;LDLR;ATF4;...
Kaposi sarcoma-associated herpesvirus infection 1.70 4.64e-2 172/193 (89.12%) CDKN1A;VEGFA;SRC;...
Non-homologous end-joining -1.53 4.33e-2 11/13 (84.62%) DCLRE1C;XRCC5;DNTT;...
RNA degradation -1.54 4.09e-2 53/79 (67.09%) CNOT7;CNOT4;CNOT9;...
Basal transcription factors -1.54 4.17e-2 37/45 (82.22%) TAF5L;CDK7;GTF2E1;...
Spinocerebellar ataxia -1.58 3.42e-2 128/143 (89.51%) AFG3L2;ATP2A1;PSMC4;...
mRNA surveillance pathway -1.61 2.57e-2 71/98 (72.45%) PPP2R3A;NUDT21;PABPC4;...
Base excision repair -1.63 1.99e-2 29/33 (87.88%) LIG3;APEX1;TDG;...
Aminoacyl-tRNA biosynthesis -1.73 7.64e-3 15/66 (22.73%) GATB;IARS2;WARS2;...
Asthma -1.75 5.66e-3 25/31 (80.65%) HLA-DOA;HLA-DPB1;HLA-DPA1;...
Oocyte meiosis -1.76 5.97e-3 90/129 (69.77%) ADCY7;RPS6KA3;CCNE2;...
Amyotrophic lateral sclerosis -1.82 1.33e-3 267/364 (73.35%) SEH1L;PRPH;PSMC4;...
Oxidative phosphorylation -1.82 1.06e-3 93/133 (69.92%) COX5A;NDUFS1;NDUFA5;...
Parkinson disease -1.84 7.54e-4 176/249 (70.68%) TRAP1;PSMC4;PARK7;...
Ribosome -1.88 8.08e-4 113/158 (71.52%) RPL7A;RPLP0;RPS21;...
Huntington disease -1.93 4.35e-4 233/306 (76.14%) AP2B1;COX8A;POLR2L;...
RNA polymerase -1.94 4.71e-4 23/31 (74.19%) POLR3D;POLR2C;POLR3G;...
Prion disease -1.94 5.14e-4 209/273 (76.56%) PSMC4;PSMB2;COX5A;...
Mismatch repair -1.97 5.66e-4 22/23 (95.65%) POLD2;MSH3;MSH6;...
Nucleotide excision repair -2.03 6.28e-4 40/47 (85.11%) DDB1;GTF2H1;ERCC4;...
Fanconi anemia pathway -2.06 7.07e-4 36/54 (66.67%) ATR;ERCC4;RPA1;...
Homologous recombination -2.16 0.00e+0 35/41 (85.37%) RAD54L;RBBP8;POLD2;...
Spliceosome -2.18 0.00e+0 101/150 (67.33%) DHX16;SF3B5;SNRPG;...
RNA transport -2.19 0.00e+0 128/186 (68.82%) NCBP2;THOC5;POP7;...
Cell cycle -2.20 0.00e+0 110/124 (88.71%) MCM4;CCNE2;ORC2;...
Ribosome biogenesis in eukaryotes -2.37 0.00e+0 52/108 (48.15%) RCL1;NOL6;MPHOSPH10;...
DNA replication -2.38 0.00e+0 34/36 (94.44%) MCM7;POLD1;MCM3;...
Proteasome -2.57 0.00e+0 44/46 (95.65%) PSMC4;PSMB2;PSMD8;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H