Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM01SR6)

• Drug Name: L-NAME Drug Info
• Synonyms: N-Nitroarginine methyl ester; NG-NITROARGININE METHYL ESTER; N(G)-Nitroarginine methyl ester; N-Nitro-L-arginine methylester; Ngamma-Nitro-L-arginine methyl ester; N(G)-Nitro-L-arginine methyl ester; N(sup G)-Nitro-L-arginine methyl ester; N-omega-Nitro-O-arginine methyl ester; Methyl (2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoate; Methyl N5-(N'-nitrocarbamimidoyl)-L-ornithinate; N(5)-(Imino(nitroamino)methyl)-L-ornithine methyl ester; N-.omega.-Nitro-O-arginine methyl ester; L-Ornithine, N(5)-(imino(nitroamino)methyl)-, methyl ester; Methyl (2S)-2-amino-5-[(amino-nitramido-methylidene)amino]pentanoate
• Cross-matching ID:
  PubChem CID: 39836
  ChEBI ID: CHEMBL7890
  CAS Number: CAS 50903-99-6
  TTD Drug ID: D0D3AI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Asthma	1.98	1.39e-2	25/31 (80.65%)	CD40;FCER1A;HLA-DQA1;...
IL-17 signaling pathway	-1.75	2.15e-2	84/94 (89.36%)	HSP90AA1;IL6;CASP3;...
Legionellosis	-1.86	6.61e-3	51/57 (89.47%)	NFKBIA;SAR1A;HSPA2;...
Proximal tubule bicarbonate reclamation	-1.87	6.61e-3	21/23 (91.3%)	ATP1A1;ATP1B2;PCK1;...
PPAR signaling pathway	-1.87	7.93e-3	66/74 (89.19%)	ADIPOQ;ACOX2;ACSL4;...
Parkinson disease	-1.89	8.26e-3	176/249 (70.68%)	ATP5F1D;PSMC2;NDUFA4L2;...
Oxidative phosphorylation	-2.02	2.20e-3	93/133 (69.92%)	COX7A2L;TCIRG1;ATP6V1H;...
Retinol metabolism	-2.10	3.31e-3	41/68 (60.29%)	CYP2C18;ADH1B;AOX1;...
Cardiac muscle contraction	-2.32	0.00e+0	64/87 (73.56%)	CACNB1;CACNA2D3;CACNA2D1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼