Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM02ANM)

Drug Name
P-1075 Drug Info
Synonyms
60559-98-0; P1075; N-Cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridylguanidine; P-1075; BRN 0480738; 2-Cyano-1-tert-pentyl-3-(3-pyridyl)guanidine; CHEMBL11458; Guanidine, N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridinyl-; N-cyano-N'-(1,1-dimethylpropyl)-N''-(3-pyridinyl)guanidine; P 1075; GUANIDINE, 2-CYANO-1-tert-PENTYL-3-(3-PYRIDYL)-; Guanidine, N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridinyl- [CAS]; SMR000466288; Tocris-1355; AC1L29NR; MLS000758317; MLS001424147; SCHEMBL2129487; SCHEMBL8747731; BDBM86250; CTK8J5792; CTK2F3712
Cross-matching ID
PubChem CID
43345
ChEBI ID
CHEMBL11458
CAS Number
CAS 60559-98-0
TTD Drug ID
D00LWF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Primary bile acid biosynthesis 1.95 2.37e-2 15/17 (88.24%) AMACR;CYP39A1;CYP7A1;...
Central carbon metabolism in cancer -1.62 4.83e-2 67/70 (95.71%) NTRK3;HK3;PIK3CD;...
Galactose metabolism -1.63 4.78e-2 26/31 (83.87%) G6PC3;PFKP;B4GALT2;...
IL-17 signaling pathway -1.64 4.73e-2 84/94 (89.36%) CCL2;CEBPB;MMP1;...
Lysosome -1.65 4.86e-2 115/128 (89.84%) CLTC;AP1G2;LAPTM5;...
Glycolysis / Gluconeogenesis -1.66 4.22e-2 56/67 (83.58%) ADH7;PCK2;DLD;...
Phagosome -1.67 4.05e-2 118/152 (77.63%) TFRC;ATP6V1C1;ITGA5;...
Nitrogen metabolism -1.70 3.50e-2 16/17 (94.12%) CA9;CA2;CA12
Leishmaniasis -1.71 3.04e-2 67/77 (87.01%) HLA-DRB1;PRKCB;ELK1;...
HIF-1 signaling pathway -1.72 3.25e-2 105/109 (96.33%) HK3;PIK3CD;PRKCB;...
Type II diabetes mellitus -1.72 3.23e-2 42/46 (91.3%) PIK3CA;ABCC8;CACNA1A;...
Focal adhesion -1.74 2.92e-2 180/201 (89.55%) ACTN1;ITGB8;ITGA7;...
TNF signaling pathway -1.74 3.08e-2 103/112 (91.96%) CREB3;CSF1;TNFRSF1B;...
Neutrophil extracellular trap formation -1.76 3.15e-2 101/189 (53.44%) SELP;RAF1;CAMP;...
Glycerolipid metabolism -1.77 3.11e-2 44/61 (72.13%) AGPAT1;AKR1A1;AKR1B1;...
B cell receptor signaling pathway -1.83 1.46e-2 71/81 (87.65%) BTK;PIK3CD;PRKCB;...
Rheumatoid arthritis -1.84 1.17e-2 78/93 (83.87%) CCL2;ATP6V1C1;MMP1;...
Insulin signaling pathway -1.84 1.36e-2 121/137 (88.32%) GSK3B;BRAF;MAP2K1;...
ECM-receptor interaction -1.86 1.40e-2 80/88 (90.91%) LAMC3;COMP;COL9A2;...
Pentose phosphate pathway -1.87 1.17e-2 25/30 (83.33%) RBKS;H6PD;G6PD;...
Fructose and mannose metabolism -1.94 1.17e-2 30/33 (90.91%) SORD;TPI1;AKR1B1;...
Steroid biosynthesis -1.98 1.17e-2 19/20 (95%) HSD17B7;FDFT1;LSS;...
Mineral absorption -2.19 0.00e+0 48/60 (80%) SLC31A1;VDR;FTH1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H