Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM02FGH)

Drug Name
UK-356618 Drug Info
Synonyms
UK 356618; 230961-08-7; CHEMBL117225; UK-356,618; SCHEMBL6437730; GTPL6528; CHEBI:94305; DTXSID50438778; MolPort-023-277-089; ZINC3924338; BDBM50097263; AKOS024458021; FT-0675728; PF 03890101; PF-03890101; UK-356618, > J-014983; BRD-K57011718-001-01-5; (R)-N*1*-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propyl]-N*4*-hydroxy-2-[3-(2-methyl-biphenyl-4-yl)-propyl]-succinamide
Cross-matching ID
PubChem CID
10370504
ChEBI ID
CHEMBL117225
CAS Number
CAS 230961-08-7
TTD Drug ID
D0NP8A

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
HIF-1 signaling pathway 2.18 0.00e+0 105/109 (96.33%) ENO2;HMOX1;EGLN3;...
Hepatocellular carcinoma 2.17 0.00e+0 135/168 (80.36%) HMOX1;NQO1;KEAP1;...
Galactose metabolism 2.12 0.00e+0 26/31 (83.87%) PFKP;HK2;HK1;...
Mineral absorption 2.08 0.00e+0 48/60 (80%) HMOX1;MT1G;MT1M;...
MicroRNAs in cancer 2.05 2.82e-3 146/310 (47.1%) HMOX1;DDIT4;MAP2K1;...
Glycolysis / Gluconeogenesis 2.05 2.35e-3 56/67 (83.58%) ENO2;PFKP;GPI;...
Starch and sucrose metabolism 2.03 2.02e-3 25/36 (69.44%) GPI;GBE1;HK2;...
Metabolism of xenobiotics by cytochrome P450 2.03 1.76e-3 49/77 (63.64%) AKR1C1;GSTA1;CBR3;...
Fructose and mannose metabolism 1.99 1.57e-3 30/33 (90.91%) PFKP;PFKFB3;HK2;...
Viral myocarditis 1.96 1.41e-3 53/60 (88.33%) CXADR;HLA-B;HLA-F;...
Proximal tubule bicarbonate reclamation 1.91 2.57e-3 21/23 (91.3%) CA2;ATP1B1;SLC4A4;...
Pathways in cancer 1.90 2.35e-3 474/531 (89.27%) COL4A5;JUN;HMOX1;...
Nitrogen metabolism 1.90 2.17e-3 16/17 (94.12%) CA2;CA12;CA9;...
Fluid shear stress and atherosclerosis 1.87 4.03e-3 123/139 (88.49%) JUN;HMOX1;NQO1;...
Shigellosis 1.86 5.64e-3 180/246 (73.17%) BNIP3;JUN;HK2;...
Gastric acid secretion 1.83 9.70e-3 63/76 (82.89%) CA2;ATP1B1;ACTB;...
Signaling pathways regulating pluripotency of stem cell... 1.83 9.96e-3 110/143 (76.92%) ID1;ID2;WNT5A;...
Epstein-Barr virus infection 1.82 1.10e-2 189/202 (93.56%) JUN;SAP30;FAS;...
Central carbon metabolism in cancer 1.81 1.11e-2 67/70 (95.71%) PFKP;SLC2A1;HK2;...
Viral carcinogenesis 1.80 1.13e-2 149/203 (73.4%) JUN;PKM;CDK2;...
Focal adhesion 1.80 1.14e-2 180/201 (89.55%) COL4A5;JUN;COL4A6;...
Folate biosynthesis 1.79 1.35e-2 23/26 (88.46%) AKR1C3;AKR1B10;CBR1;...
Renal cell carcinoma 1.78 1.47e-2 68/69 (98.55%) JUN;EGLN3;SLC2A1;...
Hippo signaling pathway 1.78 1.53e-2 120/186 (64.52%) ID1;ID2;WNT5A;...
TGF-beta signaling pathway 1.78 1.47e-2 81/94 (86.17%) ID1;ID2;ID3;...
Pentose phosphate pathway 1.78 1.57e-2 25/30 (83.33%) PFKP;GPI;ALDOC;...
Necroptosis 1.77 1.57e-2 113/159 (71.07%) TNFSF10;FAS;TNF;...
GnRH signaling pathway 1.75 1.69e-2 80/93 (86.02%) JUN;PRKCD;MAP2K1;...
Chronic myeloid leukemia 1.74 1.66e-2 72/76 (94.74%) GADD45B;MAP2K1;NFKBIA;...
Type II diabetes mellitus 1.73 1.65e-2 42/46 (91.3%) HK2;PKM;PRKCD;...
Terpenoid backbone biosynthesis -2.00 1.14e-3 18/22 (81.82%) MVD;ACAT2;DHDDS;...
Staphylococcus aureus infection -2.12 0.00e+0 72/95 (75.79%) MASP1;PLG;ITGAM;...
Protein export -2.18 0.00e+0 17/23 (73.91%) SEC11A;SPCS3;SEC62;...
Steroid biosynthesis -2.55 0.00e+0 19/20 (95%) HSD17B7;LSS;FDFT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 10uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H