Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM04LR2)

Drug Name
Floxuridine Drug Info
Synonyms
floxuridine; 50-91-9; 2'-Deoxy-5-fluorouridine; 5-Fluorodeoxyuridine; Fluorodeoxyuridine; Floxuridin; FUDR; Fluoruridine deoxyribose; Deoxyfluorouridine; 5-Fluoro-2'-deoxyuridine; FdUrd; Floxuridinum; Floxiridina; 5FdU; 5-fluoro-1-((2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1h,3h)-dione; 5-Fluoro-2-desoxyuridine; 5 Fluorodeoxyuridine; Floxuridinum [INN-Latin]; FDUR; Floxiridina [INN-Spanish]; beta-5-Fluoro-2'-deoxyuridine; 5-Fluoro-2-deoxyuridine; 5-FdUrd; 5-Fluorouracil deoxyriboside; Sterile fudr (TN); Floxuridine/5-fluorouracil
Cross-matching ID
PubChem CID
5790
ChEBI ID
CHEMBL917
CAS Number
CAS 50-91-9
TTD Drug ID
D0TS1Z
VARIDT Drug ID
DR00682
INTEDE Drug ID
DR1754

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.53 0.00e+0 34/36 (94.44%) LIG1;MCM5;RFC4;...
p53 signaling pathway 2.40 0.00e+0 63/73 (86.3%) CDKN1A;TNFRSF10B;DDB2;...
Mismatch repair 2.25 0.00e+0 22/23 (95.65%) LIG1;RFC4;RFC2;...
Epstein-Barr virus infection 2.21 0.00e+0 189/202 (93.56%) CDKN1A;DDB2;CCNE2;...
Nucleotide excision repair 2.15 0.00e+0 40/47 (85.11%) DDB2;LIG1;RFC4;...
Graft-versus-host disease 2.09 0.00e+0 32/42 (76.19%) FAS;HLA-B;IL6;...
TNF signaling pathway 2.06 0.00e+0 103/112 (91.96%) FAS;PTGS2;IL6;...
Melanoma 2.01 0.00e+0 68/72 (94.44%) CDKN1A;DDB2;GADD45A;...
Small cell lung cancer 2.00 0.00e+0 90/92 (97.83%) CDKN1A;DDB2;CCNE2;...
Herpes simplex virus 1 infection 1.97 1.17e-3 165/498 (33.13%) FAS;HLA-B;TAP1;...
Kaposi sarcoma-associated herpesvirus infection 1.96 2.13e-3 172/193 (89.12%) CDKN1A;FAS;CXCL8;...
Malaria 1.95 1.95e-3 44/50 (88%) CXCL8;IL6;CCL2;...
Glycine, serine and threonine metabolism 1.94 2.70e-3 31/40 (77.5%) PSAT1;PHGDH;GAMT;...
Allograft rejection 1.94 2.51e-3 32/38 (84.21%) FAS;HLA-B;HLA-DQA1;...
NF-kappa B signaling pathway 1.94 2.34e-3 90/104 (86.54%) CXCL8;PTGS2;PIDD1;...
Viral myocarditis 1.93 2.19e-3 53/60 (88.33%) HLA-B;HLA-DQA1;HLA-F;...
Arachidonic acid metabolism 1.93 2.06e-3 48/61 (78.69%) AKR1C3;PTGS2;PTGIS;...
One carbon pool by folate 1.92 2.60e-3 15/20 (75%) TYMS;MTHFD2;MTHFD1;...
Fanconi anemia pathway 1.92 2.46e-3 36/54 (66.67%) FANCI;BRCA1;FANCG;...
Homologous recombination 1.92 2.34e-3 35/41 (85.37%) BRCA1;POLD3;RAD51;...
Type I diabetes mellitus 1.91 2.78e-3 38/43 (88.37%) FAS;HLA-B;HLA-DQA1;...
Measles 1.91 2.66e-3 133/139 (95.68%) CCNE2;MX1;FAS;...
IL-17 signaling pathway 1.90 2.54e-3 84/94 (89.36%) CXCL8;FOSB;PTGS2;...
Influenza A 1.90 2.44e-3 156/172 (90.7%) TNFRSF10B;MX1;FAS;...
Glutathione metabolism 1.90 2.34e-3 43/57 (75.44%) CHAC1;GSTM3;RRM2;...
Pertussis 1.87 2.70e-3 64/76 (84.21%) CXCL8;C1S;IL6;...
Pancreatic cancer 1.87 2.60e-3 75/76 (98.68%) CDKN1A;DDB2;GADD45A;...
Folate biosynthesis 1.83 4.18e-3 23/26 (88.46%) AKR1C3;AKR1B10;GCH1;...
Epithelial cell signaling in Helicobacter pylori infect... 1.83 4.03e-3 62/70 (88.57%) CXCL8;HBEGF;ATP6V1D;...
Drug metabolism 1.81 5.85e-3 78/151 (51.66%) GSTM3;RRM2;UPP1;...
Vitamin digestion and absorption -1.71 3.00e-2 17/24 (70.83%) SLC5A6;MMACHC;LMBRD1;...
GnRH secretion -1.77 2.07e-2 60/64 (93.75%) PIK3CA;CACNA1H;CACNA1D;...
Spliceosome -1.85 1.38e-2 101/150 (67.33%) NCBP2;HNRNPU;MAGOH;...
Aminoacyl-tRNA biosynthesis -1.90 1.61e-2 15/66 (22.73%) IARS2;GATC;NARS2;...
mRNA surveillance pathway -1.93 2.42e-2 71/98 (72.45%) RNMT;CSTF2;NXF2;...
Ribosome -1.94 4.15e-2 113/158 (71.52%) RPL9;MRPL19;RPL11;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 1.11uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 1.11uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GP2d CVCL_1234 Homo sapiens 0.12uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 1.11uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12.5uM 72H
JHH-5 CVCL_1320 Homo sapiens 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
NCI-H1437 CVCL_1472 Homo sapiens 1.11uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 10uM 24H
HCC1588 CVCL_1263 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 10uM 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVK18 CVCL_1629 Homo sapiens 1.11uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 1.11uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 1.11uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 10uM 24H
SH-4 CVCL_1692 Homo sapiens 10uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 1.11uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 10uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H