Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM05IQU)

Drug Name
S-14506 Drug Info
Synonyms
UNII-YVO8LE53MI; S-14506; YVO8LE53MI; 135722-25-7; CHEBI:64101; S14506; 4-fluoro-N-[2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl]benzamide; 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide; NCGC00025289-01; Tocris-1771; J485.975H; GTPL24; AC1L300Q; SCHEMBL6364443; DTXSID9043986; CHEMBL1590266; CTK8G8605; MolPort-042-665-626; ZINC64725931; N-(2-(4-(7-Methoxy-1-naphthyl)piperazino)ethyl)-4-fluorobenzamide; 4-Fluoro-N-(2-(4-(7-methoxy-1-naphthyl)piperazine-1-yl)ethyl)benzamide; Benzamide, 4-fluoro-N
Cross-matching ID
PubChem CID
131906
ChEBI ID
CHEMBL64101
CAS Number
CAS 135722-25-7
TTD Drug ID
D0A6PL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Asthma 1.97 2.51e-2 25/31 (80.65%) CD40;HLA-DMB;HLA-DRB1;...
Rheumatoid arthritis 1.95 1.25e-2 78/93 (83.87%) CXCL1;ATP6V1D;CTSK;...
Chemokine signaling pathway 1.89 2.51e-2 163/192 (84.9%) CXCL1;HCK;CX3CL1;...
Sphingolipid metabolism 1.85 2.82e-2 32/49 (65.31%) PLPP3;SPHK1;SGPL1;...
Viral protein interaction with cytokine and cytokine re... 1.82 2.51e-2 84/100 (84%) CXCL1;CX3CL1;CCL2;...
Inflammatory bowel disease 1.80 2.93e-2 58/65 (89.23%) MAF;GATA3;IL6;...
Sulfur metabolism 1.80 2.51e-2 9/10 (90%) TST;SQOR;PAPSS1;...
Allograft rejection 1.78 2.82e-2 32/38 (84.21%) CD40;HLA-DMB;HLA-DRB1;...
Complement and coagulation cascades -1.96 7.44e-3 76/85 (89.41%) SERPINA1;VWF;MASP2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H